Peikai Chen

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Glioblastoma Multiforme (GBM) cells are highly invasive, infiltrating into the surrounding normal brain tissue, making it impossible to completely eradicate GBM tumors by surgery or radiation. Increasing evidence also shows that these migratory cells are highly resistant to cytotoxic reagents, but decreasing their migratory capability can re-sensitize them(More)
Subtypes are widely found in cancer. They are characterized with different behaviors in clinical and molecular profiles, such as survival rates, gene signature and copy number aberrations (CNAs). While cancer is generally believed to have been caused by genetic aberrations, the number of such events is tremendous in the cancer tissue and only a small subset(More)
—Copy number aberrations (CNAs) are frequently found in cancer genomes and believed to be tumorigenic. Unfortunately, CNAs often occur in wide regions of the cancer genome that harbor a large number of genes, making it a challenge to identify the candidate cancer drivers. Further, subtypes of cancer may be characterized with distinct CNA patterns and hence(More)
The problem of identifying genetic factors under­ lying complex and quantitative traits such as height, weight and disease susceptibility in natural popula­ tions has become a major theme of research in recent years. Aiming at revealing the inter-dependency and causal relationship between the underlying genotypes and observed phenotypes, researchers from(More)
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