Peikai Chen

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A new type of signaling network element, called cancer signaling bridges (CSB), has been shown to have the potential for systematic and fast-tracked drug repositioning. On the basis of CSBs, we developed a computational model to derive specific downstream signaling pathways that reveal previously unknown target-disease connections and new mechanisms for(More)
Glioblastoma Multiforme (GBM) cells are highly invasive, infiltrating into the surrounding normal brain tissue, making it impossible to completely eradicate GBM tumors by surgery or radiation. Increasing evidence also shows that these migratory cells are highly resistant to cytotoxic reagents, but decreasing their migratory capability can re-sensitize them(More)
BACKGROUNDS Intracranial germ cell tumors (GCTs) are rare and heterogeneous with very little is known about their pathogenesis and underlying genetic abnormalities. PROCEDURES In order to identify candidate genes and pathways which are involved in the pathogenesis of these tumors, we have profiled 62 intracranial GCTs for DNA copy number alterations(More)
Subtypes are widely found in cancer. They are characterized with different behaviors in clinical and molecular profiles, such as survival rates, gene signature and copy number aberrations (CNAs). While cancer is generally believed to have been caused by genetic aberrations, the number of such events is tremendous in the cancer tissue and only a small subset(More)
Cancer is a complex disease and within a cancer, subtypes of patients with distinct behaviors often exist. The subtypes might have been caused by different hits, such as copy number aberrations (CNAs) and point mutations, on different pathways/cells-of-origin in a common tissue/organ. Identifying the subtypes with subtype-specific drivers, i.e., hits, is(More)
Transition metal oxynitrides have now garnered growing interest in our quest for highly efficient alternatives to Pt in direct methanol alkaline fuel cells. Herein, carbon supported Co3Mo2OxN6-x was synthesized via a simple two-step approach wherein the reactants undergo refluxing and heat treatment in NH3. For the as-prepared Co3Mo2OxN6-x catalyst,(More)
Glioblastoma Multiforme (GBM) cells are highly invasive, infiltrating into the surrounding normal brain tissue, making it impossible to completely eradicate GBM tumors by surgery or radiation. Increasing evidence also shows that these migratory cells are highly resistant to cytotoxic reagents, but decreasing their migratory capability can re-sensitize them(More)
T he problem of identifying genetic factors under­ lying complex and quantitative traits such as height, weight and disease susceptibility in natural popula­ tions has become a major theme of research in recent years. Aiming at revealing the inter-dependency and causal relationship between the underlying genotypes and observed phenotypes, researchers from(More)
A new type of signaling network element, called cancer signaling bridges (CSB), has been shown to have the potential for systematic and fast-tracked drug repositioning. On the basis of CSBs, we developed a computational model to derive specific downstream signaling pathways that reveal previously unknown target–disease connections and new mechanisms for(More)