Pei-hua Yang

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Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol(More)
TGF-β is a key modulator in the regulation of cell proliferation and migration, and is also involved in the process of cancer development and progression. Previous studies have indicated that TGF-β responsiveness is determined by TGF-β receptor partitioning between lipid raft/caveolae-mediated and clathrin-mediated endocytosis. Lipid raft/caveolae-mediated(More)
For clinical application, there is a great need for small-molecule inhibitors (SMIs) that could control pathogenic effects of transforming growth factor (TGF-β) and/or modulate effects of TGF-β in normal responses. Selective SMIs of the TGF-β signaling pathway developed for therapeutics will also be powerful tools in experimentally dissecting this complex(More)
Pentabromophenol (PBP), a brominated flame retardant (BFR), is widely used in various consumer products. BFRs exert adverse health effects such as neurotoxic and endocrine-disrupting effects. In this study, we found that PBP suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors. PBP suppressed TGF-β-mediated cell migration, PAI-1(More)
PURPOSE The transforming growth factor-beta (TGF-β) pathway is an important in the initiation and progression of cancer. Due to a strong association between an elevated colorectal cancer risk and increase fecal excretion of cholest-4-en-3-one, we aim to determine the effects of cholest-4-en-3-one on TGF-β signaling in the mink lung epithelial cells (Mv1Lu)(More)
Three kinds of plant growth regulators, gibberellinA4/7 (GA4/7), 6-benzylaminopurine (BA), and chlormequat chloride (CCC), were evaluated for their ability to promote strobilus and cone production in a Chinese pine (Pinus tabuliformis Carr.) clonal seed orchard. Treatments (0, 250, 500, or 1000 mg·L−1) were applied during three periods (June–July,(More)
Arginine (Arg) is considered to have beneficial effects on placental development and function, as well as reproductive performance. The well-developed placenta is highly required in late gestation for rapid fetal growth, however, it is unknown if there is a crucial role of Arg in late gestation. Likewise, the immunological response of sows to Arg needs to(More)
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