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Association study of serotonin transporter availability and SLC6A4 gene polymorphisms in patients with major depression
The serotonin transporter (SERT) is hypothesized to be an important component of the pathophysiology of major depression (MD). The aim of this study was to use [(123)I]ADAM single-photon emissionExpand
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PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study
PurposeThe aim of this study was to assess the feasibility of using 4-[18F]-ADAM as a brain SERT imaging agent in humans.MethodsEnrolled in the study were 19 healthy Taiwanese subjects (11 men, 8Expand
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5-HT2A receptor -1438 G/A polymorphism and serotonergic antidepressant-induced sexual dysfunction in male patients with major depressive disorder: a prospective exploratory study.
INTRODUCTION To date, few studies have specifically investigated the genetic determinants of antidepressant-induced sexual dysfunction (SD). AIM The aim of this prospective study was to examineExpand
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Comparison of the efficacy and impact on cognition of glycopyrrolate and biperiden for clozapine-induced sialorrhea in schizophrenic patients: A randomized, double-blind, crossover study
BACKGROUND Clozapine-induced sialorrhea (CIS) is a subjective distressing adverse effect and occurs in 31%-57% of schizophrenic patients receiving clozapine therapy. Current pharmacotherapy on CISExpand
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Superior anti‐suicidal effects of electroconvulsive therapy in unipolar disorder and bipolar depression
Electroconvulsive therapy (ECT) has long been believed to reduce suicidal tendencies in patients with affective disorders; however, ECT recipients, who constitute the most severely ill and suicidalExpand
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Differential cytokine levels between early withdrawal and remission states in patients with alcohol dependence
Alcohol dependence (AD) leads to altered innate and adaptive immune responses, and frequently co-occurs with inflammation. Therefore, inflammatory cytokines potentially play a crucial role in theExpand
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Dopamine transporter gene may be associated with bipolar disorder and its personality traits
Dopamine transporter and its genetic factors have been suggested to play a critical role in the development of bipolar disorder (BPD). However, the importance of the dopamine transporter gene (DAT1)Expand
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Changes in cytokine and chemokine expression distinguish dysthymic disorder from major depression and healthy controls
An important area of uncertainty is the inflammatory degree to which depression occurring as part of dysthymic disorder may differ from major depression. Using a 27-plex cytokine assay, we analyzedExpand
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Incongruent Reduction of Serotonin Transporter Associated with Suicide Attempts in Patients with Major Depressive Disorder: A Positron Emission Tomography Study with 4-[18F]-ADAM
Background: Much evidence supports the role of the serotonin transporter (SERT) in the pathophysiology and pharmacotherapy of major depressive disorder (MDD) and suicidal behaviors. Methods: In thisExpand
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