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Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene. It is characterized by iron accumulation in the brain and in visceral organs. However, little is known about the mechanism of iron transport in these regions. Adult CP null (CP(-/-)) mice show increased iron deposition in several regions of brain, such(More)
Bmi-1 is a transcriptional regulator that promotes tumor cell self-renewal and epithelial to mesenchymal transition and its upregulation is associated with tumor progression, AMPK is an intracellular fuel-sensing enzyme and plays important roles in tumor cell growth and progression. Thus, the present study aims to examine the regulation of Bmi-1 by AMPK.(More)
Abstract We evaluated the efficacy of the anti-CD20 monoclonal antibody rituximab in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus for treating diffuse large B-cell lymphoma (DLBCL). The combination of rituximab and everolimus was more effective for inhibiting cell growth compared with single-agent therapy. An increase in(More)
This study aims at developing new organoselenium compounds with good anticancer ability and low biotoxicity. Sucrose selenious ester (sucrose-Se) was synthesized by the reaction between sucrose and selenium oxychloride. MTT assay showed that sucrose-Se effectively inhibited the proliferation of cervical cancer cell line HeLa in a dose-dependent manner(More)
A mechanism involving evolutionary genetic programming (GP) and the expectation maximization algorithm (EM) is proposed to generate feature functions, based on the primitive features, for an image pattern recognition system on the diagnosis of the disease OPMD. Experiments show that the propose algorithm achieves an average performance of 90.20% recognition(More)
Hepcidin, a principle regulator of iron metabolism, is synthesized by the liver. Contradictory results have been reported on the regulation of hepcidin expression in response to serum transferrin saturation and liver iron content. In the present study, we explore the expression of murine hepcidin mRNA and further analyze the relationship between liver(More)
A major challenge of combinatorial therapy is the unification of the pharmacokinetics and cellular uptake of various drug molecules with precise control of the dosage thereby maximizing the combined effects. To realize ratiometric delivery and synchronized release of different drugs from a single carrier, a novel approach was designed in this study to load(More)