Pei Fang Guo

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Aceruloplasminemia is an autosomal recessive disorder caused by mutations in the ceruloplasmin (CP) gene. It is characterized by iron accumulation in the brain and in visceral organs. However, little is known about the mechanism of iron transport in these regions. Adult CP null (CP(-/-)) mice show increased iron deposition in several regions of brain, such(More)
In pattern detection systems, the general techniques of feature extraction and selection perform linear transformations from primitive feature vectors to new vectors of lower dimensionality. At times, new extracted features might be linear combinations of some primitive features that are not able to provide better classification accuracy. To solve this(More)
Abstract We evaluated the efficacy of the anti-CD20 monoclonal antibody rituximab in combination with the mammalian target of rapamycin (mTOR) inhibitor everolimus for treating diffuse large B-cell lymphoma (DLBCL). The combination of rituximab and everolimus was more effective for inhibiting cell growth compared with single-agent therapy. An increase in(More)
This study aims at developing new organoselenium compounds with good anticancer ability and low biotoxicity. Sucrose selenious ester (sucrose-Se) was synthesized by the reaction between sucrose and selenium oxychloride. MTT assay showed that sucrose-Se effectively inhibited the proliferation of cervical cancer cell line HeLa in a dose-dependent manner(More)
A major challenge of combinatorial therapy is the unification of the pharmacokinetics and cellular uptake of various drug molecules with precise control of the dosage thereby maximizing the combined effects. To realize ratiometric delivery and synchronized release of different drugs from a single carrier, a novel approach was designed in this study to load(More)
A mechanism involving evolutionary genetic programming (GP) and the expectation maximization algorithm (EM) is proposed to generate feature functions, based on the primitive features, for an image pattern recognition system on the diagnosis of the disease OPMD. Experiments show that the propose algorithm achieves an average performance of 90.20% recognition(More)
The purpose of this study is to explore an alternative means of hand image classification, one that requires minimal human intervention. The main tool for accomplishing this is a Genetic Algorithm (GA). This study is more than just another GA application; it introduces (a) a novel cooperative coevolutionary clustering algorithm with dynamic clustering and(More)
A mechanism involving evolutionary genetic programming (GP) and the expectation maximization algorithm (EM) is proposed to generate feature functions automatically, based on the primitive features, for an image pattern recognition system on the diagnosis of the disease OPMD. Prior to the feature function generation, we introduce a novel technique of the(More)
Cytarabine (Ara-c) has been an important agent in acute myeloid leukemia (AML) treatment for more than 40 years. While, the mechanisms underlying low dose cytarabine (LD Ara-c) is poorly understood. In this study, we investigated the therapeutic effect of LD Ara-C in vitro. U937 and HEL cell lines were treated with increasing dose of Ara-C and showed growth(More)