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Astrocytes support neuronal antioxidant capacity by releasing glutathione, which is cleaved to cysteine in brain extracellular space. Free cysteine is then taken up by neurons through excitatory amino acid transporter 3 [EAAT3; also termed Slc1a1 (solute carrier family 1 member 1)] to support de novo glutathione synthesis. Activation of the nuclear factor(More)
Localization is a fundamental and essential issue for wireless sensor networks (WSNs). Existing localization algorithms can be categorized as either range-based or range-free schemes. Range-based schemes are not suitable for WSNs because of their irregularity of radio propagation and their cost of additional devices. In contrast, range-free schemes do not(More)
Transcriptional activation of protective genes is mediated by a cis-acting element called the antioxidant responsive element (ARE). The transcription factor Nrf2 (NF-E2-related factor 2) binds to the ARE. Activation of this pathway protects cells from oxidative stress-induced cell death. Increased oxidative stress is associated with neuronal cell death(More)
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. It is known that under conditions of oxidative stress, the transcription factor NF-E2-related factor (Nrf2) binds to antioxidant response element (ARE) to induce antioxidant and phase II(More)
Machine reading calls for programs that read and understand text, but most current work only attempts to extract facts from redundant web-scale corpora. In this paper , we focus on a new reading comprehension task that requires complex reasoning over a single document. The input is a paragraph describing a biological process , and the goal is to answer(More)
BACKGROUND We investigated the association between cardiovascular disease (CVD) and the risk of major osteoporotic fracture in Taiwan. METHODS Using the Taiwan National Health Insurance Database for the period 2000-2007, we classified 43 874 patients aged 50 years or older with newly diagnosed CVD (coronary artery disease, heart failure, cerebrovascular(More)
Antrodia camphorata (A. camphorata) is well known in Taiwan as a traditional Chinese medicine. The purpose of this study was to evaluate the ability of aqueous extract from A. camphorata mycelia to protect normal human erythrocytes against oxidative damage in vitro. Oxidative hemolysis and lipid/protein peroxidation of erythrocytes induced by the aqueous(More)
BACKGROUND The causal association between diabetes and pancreatic cancer remains unclear in Asian populations. This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a Taiwanese population. METHODS Using claims(More)
OBJECTIVES Using population-based representative insurance claims data, the risk of developing hepatocellular carcinoma (HCC) among diabetes mellitus (DM) patients, as well as whether DM medications alter the risk of developing HCC were investigated. METHODS From the Taiwan National Health Insurance Research Database, 19,349 newly diagnosed DM patients 20(More)