• Publications
  • Influence
p53 downstream target DDA3 is a novel microtubule-associated protein that interacts with end-binding protein EB3 and activates β-catenin pathway
We have previously identified mouse DDA3 as a p53-inducible gene. To explore the functional role of DDA3, we screened a mouse brain cDNA library by the yeast two-hybrid assay, and identified theExpand
  • 41
  • 3
Rad is a p53 direct transcriptional target that inhibits cell migration and is frequently silenced in lung carcinoma cells
The p53 tumor suppressor exerts its function mainly as a transcriptional activator. Here we show that the Ras-related small GTPase Rad, an inhibitor of Rho kinase, is a direct transcriptional targetExpand
  • 21
  • 3
CHD1L Regulated PARP1‐Driven Pluripotency and Chromatin Remodeling During the Early‐Stage Cell Reprogramming
PARP1 and poly(ADP‐ribosyl)ation (PARylation) have been shown to be essential for the initial steps of cellular reprogramming. However, the mechanism underlying PARP1/PARylation‐regulated activationExpand
  • 16
  • 1
Targeting autophagy enhances BO-1051-induced apoptosis in human malignant glioma cells
PurposeBO-1051 is an N-mustard derivative that is conjugated with DNA-affinic 9-anilinoacridine. Since BO-1051 was reported to have strong anticancer activity, we investigated the effect andExpand
  • 14
p53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation.
The p53 tumor suppressor functions in maintaining the integrity of the genome. We have previously reported that DDA3 is an oncoprotein transcriptionally regulated by p53. To explore mechanismsExpand
  • 16
DDA3 stabilizes microtubules and suppresses neurite formation
Summary We have previously shown that DDA3 – also known as proline/serine-rich coiled-coil protein 1 (PSRC1) – is a microtubule-associated protein that promotes cell growth by stimulating theExpand
  • 9
  • PDF