Pedro Vale Estrela

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The inability to diagnose numerous diseases rapidly is a significant cause of the disparity of deaths resulting from both communicable and non-communicable diseases in the developing world in comparison to the developed world. Existing diagnostic instrumentation usually requires sophisticated infrastructure, stable electrical power, expensive reagents, long(More)
Over the past three decades effort has been devoted to exploit the field-effect mechanism in chemical and biological sensors, due to the potential of these devices to provide large arrays of sensors that are label-free, low-cost, disposable and can be easily integrated in portable instrumentation. Most of this work concerned the development of ion-sensitive(More)
All IP mobility protocols currently proposed by the IETF assume that the mobile nodes always have a mobility-aware IP stack, which is still a scenario that can seldom be found nowadays. Most terminals, including the laptops and PDAs which would most benefit of the mobility support, still use legacy IP stacks, limiting their use to layer 2 mobility within a(More)
All the proposed IP mobility protocols assume that the mobile nodes always have a mobility-aware IP stack. On the other hand, efficient micro-mobility solutions entail specific topologies and mobile-aware routers, requiring major changes in the existing infra-structures. Major advantages are foreseen if mobility can be supported using the existing legacy(More)
Microarrays based on DNA-DNA hybridization are potentially useful for detecting and subtyping viruses but require fluorescence labeling and imaging equipment. We investigated a label-free electrical detection system using electrochemical impedance spectroscopy that is able to detect hybridization of DNA target sequences derived from avian H5N1 influenza(More)
Over the past decade, electrical detection of chemical and biological species using novel nanostructure-based devices has attracted significant attention for chemical, genomics, biomedical diagnostics, and drug discovery applications. The use of nanostructured devices in chemical/biological sensors in place of conventional sensing technologies has(More)
The discovery of the phenomena known as localized surface plasmon resonance (LSPR) has provided the basis for many research areas, ranging from materials science to biosensing. LSPR has since been viewed as a transduction platform that could yield affordable, portable devices for a multitude of applications. This review aims to outline the potential(More)
In the field of mobility support, several mobility protocols resort to the use of triangulation mechanisms as a means of supporting fast handovers or basic connectivity. In order to reduce the maximum end-to-end delay of the packets, such triangulations can be later removed to enable direct routing of the data packets. However, using a simple update of this(More)
This paper describes a Terminal's Independent Mobility Architecture, TIMIP / sMIP, which supports IP mobility of legacy terminals, and presents a complete performance evaluation to compare the proposed architecture with alternative solutions, via simulation studies in complex scenarios featuring wired mesh topologies and wireless disjoint channels. The NS2(More)
Phosphorylation is the most important post-translational modification of proteins in eukaryotic cells and it is catalysed by enzymes called kinases. The balance between protein phosphorylation and dephosphorylation is critical for the regulation of physiological processes and its unbalance is the cause of several diseases. Conventional assays used to(More)