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In a previous work, we studied the interaction of beta-amyloid fibrils (Abeta) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the peptide CLPFFD-NH2 on the efficiency of conjugation to AuNP, the stability of the conjugates, and the affinity of the conjugates to the Abeta(More)
A self-biased current reference based on the MOSFET Zero Temperature Coefficient (ZTC) condition is presented. It can be implemented in any CMOS process and it provides a simple alternative to design a reference current suitable for low TC biasing. This topology was designed in a 0.18 μm process to generate 5 μA under a supply voltage from 1.4V to 1.8(More)
The continuous scaling of CMOS devices has required the consequent reduction of the supply voltages. There is a need for analog and RF circuits able to operate under at supplies lower than 0.5 V. This paper presents a voltage reference based on the MOSFET zero-temperature condition (ZTC) that operates with a low 0.5 V supply. The circuit is composed by a(More)
—A variable transimpedance amplifier suitable for low power wireless personal area network is presented from top-level specifications to circuit level design. Its specifications are defined and justified for a direct conversion receiver architecture. A multiple-feedback-loop topology which allows for programmable gain, constant bandwidth, and DC attenuation(More)
(1) Superintendency for the Control of Endemic Diseases/SUCEN, São Paulo, SP, Brazil. (2) Faculty of Public Health, USP, São Paulo, SP, Brazil. (3) Parasitology Laboratory, Butantan Institute, São Paulo, SP, Brazil. Correspondence to: Marisa Cristina de Almeida Guimarães, Laboratório de Malacologia da Superintendência de Controle de Endemias (Sucen), Rua(More)
An electromagnetic interference (EMI) source can significantly degrade the performance of a current reference since its finite Power Supply Rejection Ratio (PSRR) of the later. For that reason A modified current reference with high immunity to EMI and a new current mirror structure insensitive to induced EMI are proposed based on the classic boot-strapped(More)
BACKGROUND: Studies have demonstrated that some polymorphisms in diff erent interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) –251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS AND METHODS: A case-control study was conducted on patients with noncardia(More)
The necessary conditions to design MOSFET transconductors with low temperature dependence are analysed and defined in this paper. Transconductors, or Gm circuits, are fundamental blocks used to implement adjustable filters, multipliers, controlled oscillators, amplifiers and a large variety of analog circuits. Temperature stability is a must in such(More)
19 Renal artery stenosis is the main cause of renovascular hypertension and results in 20 ischemic nephropathy characterized by inflammation, oxidative stress, microvascular 21 loss and fibrosis with consequent functional failure. Considering the limited number of 22 strategies that effectively control renovascular hypertension and restore renal function,(More)