Pedro Toledo

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In a previous work, we studied the interaction of beta-amyloid fibrils (Abeta) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the peptide CLPFFD-NH2 on the efficiency of conjugation to AuNP, the stability of the conjugates, and the affinity of the conjugates to the Abeta(More)
INTRODUÇÃO O Vale do Ribeira, região situada no sudeste do Estado de São Paulo, apresen-ta uma bacia hidrográfica formada pelo Rio Ribeira do Iguape e por extensa rede hídrica que confere àquela zona ca-racterísticas especiais; entre os fatôres cli-máticos, destaca-se a pluviosidade média anual de 2.500 mm, que nas áreas de culturas, especialmente bananas,(More)
A self-biased current reference based on the MOSFET Zero Temperature Coefficient (ZTC) condition is presented. It can be implemented in any CMOS process and it provides a simple alternative to design a reference current suitable for low TC biasing. This topology was designed in a 0.18 μm process to generate 5 μA under a supply voltage from 1.4V to 1.8(More)
—A variable transimpedance amplifier suitable for low power wireless personal area network is presented from top-level specifications to circuit level design. Its specifications are defined and justified for a direct conversion receiver architecture. A multiple-feedback-loop topology which allows for programmable gain, constant bandwidth, and DC attenuation(More)
BACKGROUND: Studies have demonstrated that some polymorphisms in diff erent interleukin genes may increase the risk of cancer. The aim of this study was to investigate the association between the IL-8 (rs4073) –251A/T gene polymorphism and the risk of gastric cancer (GC). PATIENTS AND METHODS: A case-control study was conducted on patients with noncardia(More)
An electromagnetic interference (EMI) source can significantly degrade the performance of a current reference since its finite Power Supply Rejection Ratio (PSRR) of the later. For that reason A modified current reference with high immunity to EMI and a new current mirror structure insensitive to induced EMI are proposed based on the classic boot-strapped(More)
SUMMARY — Case report of a 7 1/2-years old girl considered as being normal until the age of 2 years. From then on she progressed with gait disturbance, mental deterioration, dystonic movements, convulsions and dysarthria. She died of bronchopneumonia one year later. CT scan showed hyperdensity at the putamina, with no signs of cerebral atrophy. Pathological(More)