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Multicast potentially optimises bandwidth consumption and node resources, when several users simultaneously participate in a communication session. Nevertheless, contrary to the expectations, IP multicast has not experienced widespread deployment, with the exception of IPTV. On the other hand, emerging Wireless Sensor Network (WSN) applications could(More)
Hereditary breast/ovarian cancer syndrome is caused by germline deleterious mutations in BRCA1 and BRCA2. A major problem of genetic testing and counseling is the finding of variants of uncertain significance (VUS). We sought to ascertain the pathogenicity of 25 BRCA1 and BRCA2 VUS identified in Portuguese families during genetic testing. We performed(More)
This paper describes MATISSE, a MATLAB to C compiler targeting embedded systems that is based on Strategic and Aspect-Oriented Programming concepts. MATISSE takes as input: (1) MATLAB code and (2) LARA aspects related to types and shapes, code insertion/removal, and specialization based directives defining default variable values. In this paper we also(More)
BACKGROUND PALB2 has emerged as a breast cancer susceptibility gene. Mutations in PALB2 have been identified in almost all breast cancer populations studied to date, but the rarity of these mutations and lack of information regarding their penetrance makes genetic counseling for these families challenging. We studied BRCA1/2 -negative breast and/or ovarian(More)
Sulforaphane (SFN) is a naturally-occurring isothiocyanate best known for its role as an indirect antioxidant. Notwithstanding, in different cancer cell lines, SFN may promote the accumulation of reactive oxygen species (ROS) and cause cell death e.g. by apoptosis. Osteosarcoma often becomes chemoresistant, and new molecular targets to prevent drug(More)
Mobility is one of the most important issues in next generation networks. As wireless sensor networks are becoming the next elements of the future Internet, it is crucial to study new models that also support mobility of these nodes. This paper presents and studies three paradigms to support mobility in sensor nodes. This study is supported by prototyping.(More)
Prostate cancer (PrCa) is one of the most common cancers diagnosed worldwide and 5–10 % of all cases are estimated to be associated with inherited predisposition. Even though there is strong evidence that the genetic component is significant in PrCa, the genetic etiology of familial and early-onset disease is largely unknown. Although it has been suggested(More)
Molecular diagnosis of hereditary breast and ovarian cancer (HBOC) by standard methodologies has been limited to the BRCA1 and BRCA2 genes. With the recent development of new sequencing methodologies, the speed and efficiency of DNA testing have dramatically improved. The aim of this work was to validate the use of next-generation sequencing (NGS) for the(More)
To determine whether a large genomic rearrangement is actually novel and to gain insight about the mutational mechanism responsible for its occurrence, molecular characterization with breakpoint identification is mandatory. We here report the characterization of two large deletions involving the BRCA1 gene. The first rearrangement harbored a 89 664-bp(More)
Purpose BRCA1/2 mutations increase the risk of breast and prostate cancer in men. Common genetic variants modify cancer risks for female carriers of BRCA1/2 mutations. We investigated-for the first time to our knowledge-associations of common genetic variants with breast and prostate cancer risks for male carriers of BRCA1/ 2 mutations and implications for(More)