Pedro Ortiz

Learn More
Two protocols were tested to assess anticonvulsant efficacy and drug concentrations after intracerebroventricular (i.c.v.) continuous valproic acid (VPA) infusion, as compared with acute injections in the kindling epilepsy model. Protocol 1: amygdala-kindled rats were injected via intraperitoneal (i.p.) and i.c.v. routes with varying doses of VPA and tested(More)
We analyzed the effects of S-adenosyl-L-methionine (SAM) on tissue oxidative status in a combined model of permanent focal ischemia and global reperfusion in the rat brain. The production of thiobarbituric acid reactive substances (TBARS) was measured under basal conditions and after induction with ferrous salt as an indicator of brain lipid peroxidation.(More)
Automatic detection of persuasion is essential for machine interaction on the social web. To facilitate automated persuasion detection, we present a novel microtext corpus derived from hostage negotiation transcripts as well as a detailed manual (codebook) for persuasion annotation. Our corpus , called the NPS Persuasion Corpus, consists of 37 transcripts(More)
Human and animal fascioliasis is emerging in many world regions, among which Andean countries constitute the largest regional hot spot and Peru the country presenting more human endemic areas. A survey was undertaken on the lymnaeid snails inhabiting the hyperendemic area of Cajamarca, where human prevalences are the highest known among the areas presenting(More)
BACKGROUND Fascioliasis and paragonimiasis are widespread foodborne trematode diseases, affecting millions of people in more than 75 countries. The treatment of choice for these parasitic diseases is based on triclabendazole, a benzimidazole derivative which has been suggested as a promising drug to treat pregnant women and children. However, at the moment,(More)
BACKGROUND Polybrominated diphenyl ethers (PBDEs) are structurally similar to polychlorinated biphenyls (PCBs) and have both central (learning and memory deficits) and peripheral (motor dysfunction) neurotoxic effects at concentrations/doses similar to those of PCBs. The cellular and molecular mechanisms for these neurotoxic effects are not fully(More)
Rheoencephalography (REG) is impedance plethysmography applied to the head, and provides an indirect measurement of the pulsatility of the cerebral blood volume. To extend REG as a clinical and research tool, it is necessary to evaluate the sensitivity of REG measurement to local brain conductivity changes. By means of the analytical solution of a(More)
  • 1