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A novel automatic 3D+time left ventricle (LV) segmentation framework is proposed for cardiac magnetic resonance (CMR) datasets. The proposed framework consists of three conceptual blocks to delineate both endo and epicardial contours throughout the cardiac cycle: (1) an automatic 2D mid-ventricular initialization and segmentation; (2) an automatic stack(More)
The phytoalexin resveratrol (RESV), a defensive substance produced by plants in response to infection by pathogenic microorganisms, displays a wide range of biological effects in mammalian cells. In the present study, we analysed the in vitro effect of RESV on the amphizoic ciliate Philasterides dicentrarchi and demonstrated for the first time that this(More)
The purpose of the present study was to understand the energetic, biomechanical and coordinative changes occurring throughout the transition of the lactate threshold. Twelve high-level swimmers (six males and six females) performed a paced intermittent incremental protocol of 7 × 200 m (0.05 m s−1 increments and 30 s intervals). The stroking parameters(More)
The Asian clam, Corbicula fluminea, is among the most pervasive invasive species in freshwater ecosystems worldwide. Our objective was to study C. fluminea’s functional response in terms of feeding behavior and food selectivity, using the natural variation in organic matter (OM) sources that occur in estuarine environments. Using C and N stable isotopes, we(More)
This study aimed to determine whether and how the disruption of river flow, during the filling of the Alqueva dam, influenced the variability of abiotic and biotic factors in the Guadiana estuary, particularly the abundance and distribution of anchovy eggs. River inflow was found to be the most important factor in determining abiotic and biotic variability(More)
Alzheimer's disease is a complex neurodegenerative disorder of the central nervous system, characterized by amyloid-β deposits, τ-protein aggregation, oxidative stress and reduced levels of acetylcholine in the brain. One pharmacological approach is to restore acetylcholine level by inhibiting acetylcholinesterase (AChE) with reversible inhibitors, such as(More)
The aim of this work is to present a simple, practical and efficient protocol for drug design, in particular Diabetes, which includes selection of the illness, good choice of a target as well as a bioactive ligand and then usage of various computer aided drug design and medicinal chemistry tools to design novel potential drug candidates in different(More)
The phytoalexin resveratrol (RESV) displays antiparasitic activity against Philasterides dicentrarchi, a scuticociliate pathogen of turbot, and causes oxidative stress, inhibition of antioxidant enzyme activity and morphological alterations in the parasite mitochondria. In this study, we analysed the mitochondrial biology of P. dicentrarchi and assessed the(More)