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OBJECTIVES It is still a matter of debate whether variables such as education, sex, age, personality and others underlie subjective memory complaints (SMC). Our objectives are to study: the prevalence of memory complaints in the city of Madrid, the distribution of complaints in the population according to socio-demographic variables and the related(More)
Although progressive functional brain network disruption has been one of the hallmarks of Alzheimer's Disease, little is known about the origin of this functional impairment that underlies cognitive symptoms. We investigated how the loss of white matter (WM) integrity disrupts the organization of the functional networks at different frequency bands. The(More)
OBJECTIVES We investigate whether Subjective Memory Complaints (SMC) are associated with specific aspects of quality of life and activities of daily living. METHODS Cross-sectional descriptive epidemiological study (random sample of the non-institutionalized census population): 1637 subjects over 64 years. SMC were obtained through questions regarding(More)
OBJECTIVE Subjective memory complaints (SMCs) are frequently reported by elderly people with or without objective cognitive impairment (OMI) as assessed by neuropsychological tests. We investigate whether SMCs are associated with altered brain biomagnetic patterns even in the absence of OMI. METHODS We report spatio-temporal patterns of brain magnetic(More)
People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer's disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between(More)
It is still an open question whether subjective memory complaints (SMC) can actually be considered to be clinically relevant predictors for the development of an objective memory impairment and even dementia. There is growing evidence that suggests that SMC are associated with an increased risk of dementia and with the presence of biological correlates of(More)
INTRODUCTION Neurological consultations due to memory complaints have increased in recent years in both older and younger people. Few investigations have studied the variables related to memory complaints in young adults. AIM To analyze, in a sample of young adults, the relationship between memory complaints and objective memory performance, depressive(More)
Mild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic(More)
differ from those in dementia of the Alzheimer type (DAT), where there is atrophy of the CA1 and subiculum subfields. This suggests that hippocampal damage in PPA is different from that in DAT, and may reflect disparities in underlying neuropathology. Background: Previous studies of the dementia continuum have characterized the early disruption of the brain(More)
BACKGROUND Most research points to the ɛ4 allele of the apolipoprotein E (APOE) gene as the most recognizable genetic risk factor associated with Alzheimer's disease pathogenesis. It has been also suggested that the APOEɛ4 allele has a negative influence on cognitive functioning, which begins long before cognitive impairment becomes manifest. However,(More)