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Human embryonic stem cell (hESC) and reprogrammed/induced pluripotent stem cell (iPSC) research is becoming the ''flavor of the month'' for downstream applications such as drug screening, disease modeling, and future regenerative medicine and cell therapies [1–4]. Pluripotency (the ability to give rise to any cell type of the three germ layers: mesoderm,(More)
The TLX1 oncogene (encoding the transcription factor T cell leukemia homeobox protein-1) has a major role in the pathogenesis of T cell acute lymphoblastic leukemia (T-ALL). However, the specific mechanisms of T cell transformation downstream of TLX1 remain to be elucidated. Here we show that transgenic expression of human TLX1 in mice induces T-ALL with(More)
Gamma-secretase inhibitors (GSIs) block the activation of oncogenic NOTCH1 in T-cell acute lymphoblastic leukemia (TALL). However, limited antileukemic cytotoxicity and severe gastrointestinal toxicity have restricted the clinical application of these targeted drugs. Here we show that combination therapy with GSIs plus glucocorticoids can improve the(More)
The locked-in syndrome (LIS) is a state of an upper motor neurone quadriplegia involving the cranial nerve pairs with usually a lateral gaze palsy, paralytic mutism, full consciousness and awareness by the patient of his environment. A historical presentation of the LIS is given as well as a short description of the clinicoanatomic lesion causing LIS. The(More)
We present here a combinatorial method for computing Steenrod squares of a simplicial set X. This method is essentially based on the determination of explicit formulae for the component morphisms of a higher diagonal approximation (i.e., a family of morphisms measuring the lack of commutativity of the cup product on the cochain level) in terms of face(More)
Human induced pluripotent stem cells (hiPSC) have been generated from different tissues, with the age of the donor, tissue source and specific cell type influencing the reprogramming process. Reprogramming hematopoietic progenitors to hiPSC may provide a very useful cellular system for modelling blood diseases. We report the generation and complete(More)
We present a new solution for the Homology Groups of Binary 2D Image (HGB2I) Problem by using Membrane Computing techniques. This is a classical problem in Homology Theory which tries to calculate the number of connected components and the representative curves of the holes of these components from a given binary 2D image. To this aim, we present a family(More)
In this paper, working over Z (p) and using algebra perturbation results from [18], p-minimal homological models of twisted tensor products (TTPs) of Car-tan's elementary complexes are obtained. Moreover, making use of the notion of indecomposability of a TTP, we deduce that a homological model of a inde-composable p-minimal TTP of length (≥ 2) of exterior(More)
Once a discrete Morse function has been defined on a finite cell complex, information about its homology can be deduced from its critical elements. The main objective of this paper is to define optimal discrete gradient vector fields on general finite cell complexes, where optimality entails having the least number of critical elements. Our approach is to(More)
Cohomology operations (including the cohomology ring) of a geometric object are finer algebraic invariants than the homology of it. In the literature, there exist various algorithms for computing the homology groups of simplicial complexes ([Mun84], [DE95,ELZ00], [DG98]), but concerning the algorithmic treatment of cohomology operations, very little is(More)