Pedro J. Rodrigues

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N-benzyladriamycin-14-valerate (AD 198) is pharmacologically superior to Adriamycin (ADR) based upon comparable cytotoxicity, decreased cardiotoxicity and the ability of AD 198 to circumvent multidrug resistance conferred by either P-glycoprotein overexpression or reduced topoisomerase II activity. AD 198, however, suffers from systemic lability of the(More)
We want to create a working tool for mathematics teachers and a corresponding learning tool for students, namely a graphical simulator of mathematical algorithms (GraSMa). To achieve it we try two different strategies. We started by annotate manually the original algorithm with inspector functions. Now we are testing a new approach that aims to(More)
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