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Transcriptomics throughout the life cycle of Leishmania infantum: high down-regulation rate in the amastigote stage.

• Pedro J Alcolea, Ana Alonso, +4 authors Vicente Larraga
• International journal for parasitology
• 2010

Leishmania infantum is the causative agent of zoonotic visceral leishmaniasis in the Mediterranean Basin. The promastigote and amastigote stages alternate in the life cycle of the parasite,… (More)

Genome-wide analysis reveals increased levels of transcripts related with infectivity in peanut lectin non-agglutinated promastigotes of Leishmania infantum.

• Pedro J Alcolea, Ana Alonso, +5 authors Vicente Larraga
• Genomics
• 2009

Metacyclic promastigotes are transmitted during bloodmeals after development inside the gut of the sandfly vector. The isolation from axenic cultures of procyclic and metacyclic promastigotes by… (More)

Temperature increase prevails over acidification in gene expression modulation of amastigote differentiation in Leishmania infantum

• Pedro J Alcolea, Ana Alonso, +6 authors Vicente Larraga
• BMC Genomics
• 2009

The extracellular promastigote and the intracellular amastigote stages alternate in the digenetic life cycle of the trypanosomatid parasite Leishmania. Amastigotes develop inside parasitophorous… (More)

Proteome profiling of Leishmania infantum promastigotes.

• Pedro J Alcolea, Ana Alonso, Vicente Larraga
• The Journal of eukaryotic microbiology
• 2011

A proteome analysis of the promastigote stage of the trypanosomatid parasite Leishmania infantum (MON-1 zymodeme) is described here for the first time. Total protein extracts were prepared at early… (More)

Structure of tyrosine aminotransferase from Leishmania infantum

• Monica A. Moreno, AndreyY. Abramov, +7 authors Vicente Larraga
• Acta crystallographica. Section F, Structural…
• 2014

The trypanosomatid parasite Leishmania infantum is the causative agent of visceral leishmaniasis (VL), which is usually fatal unless treated. VL has an incidence of 0.5 million cases every year and… (More)

Stage-specific differential gene expression in Leishmania infantum: from the foregut of Phlebotomus perniciosus to the human phagocyte

• Pedro J Alcolea, Ana Alonso, +4 authors Vicente Larraga
• BMC Genomics
• 2014

Leishmania infantum is the etiological agent of zoonotical visceral leishmaniasis in the Mediterranean basin. A recent outbreak in humans has been recently reported in central Spain. Leishmania spp.… (More)

Genome-wide gene expression profile induced by exposure to cadmium acetate in Leishmania infantum promastigotes.

• Pedro J Alcolea, Ana Alonso, Vicente Larraga
• International microbiology : the official journal…
• 2011

Leishmania infantum is the etiological agent of visceral leishmaniasis in Mediterranean areas. The life cycle of the protist is dimorphic and heteroxene, as promastigotes develop inside the gut of… (More)

Nickel-Resistance Determinants in Acidiphilium sp. PM Identified by Genome-Wide Functional Screening

• Patxi San Martín-Úriz, Salvador Mirete, Pedro J Alcolea, Manuel J. Gómez, Ricardo Amils, José Eduardo Gónzalez-Pastor
• PloS one
• 2014

Acidiphilium spp. are conspicuous dwellers of acidic, metal-rich environments. Indeed, they are among the most metal-resistant organisms; yet little is known about the mechanisms behind the metal… (More)

Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection.

• Irma Ramos, Ana Alonso, +5 authors Vicente Larraga
• Vaccine
• 2009

Canine visceral leishmaniasis is a serious public health concern in the Mediterranean basin since dogs are the main Leishmania infantum reservoir. However, there is not a vaccination method in… (More)

In vitro infectivity and differential gene expression of Leishmania infantum metacyclic promastigotes: negative selection with peanut agglutinin in culture versus isolation from the stomodeal valve…

• Pedro J Alcolea, Ana Alonso, +4 authors Vicente Larraga
• BMC Genomics
• 2016

Leishmania infantum is the protozoan parasite responsible for zoonotic visceral leishmaniasis in the Mediterranean basin. A recent outbreak in humans has been reported in this area. The life cycle of… (More)

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