Pedro Alberto Lamothe

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To demonstrate the presence of endothelial dysfunction (ED) in asymptomatic patients with type 2 diabetes mellitus (DM) by using 13N-ammonia–positron emission tomography (PET). PET can identify ED by quantifying myocardial blood flow (MBF) during rest, cold pressor test (CPT), and pharmacologic stress. The endothelial-dependent vasodilation index (EDVI),(More)
Immune control of viral infections is modulated by diverse T cell receptor (TCR) clonotypes engaging peptide-MHC class I complexes on infected cells, but the relationship between TCR structure and antiviral function is unclear. Here we apply in silico molecular modeling with in vivo mutagenesis studies to investigate TCR-pMHC interactions from multiple CTL(More)
Diagnostic algorithms, as well as the biotechnological design, require the calculation of conditional probability, given the presence of certain positive data, in the context of prevalence, sensitivity and specificity; It is necessary to estimate the probability that the patient has a certain disease. Sometimes, with a test of scrutiny, it goes from a(More)
Conquering the AIDS epidemic remains one of the most challenging global health issues. Despite impressive advances in combination antiretroviral therapy (cART) to treat HIV, and substantial progress in the development of prevention interventions, a protective vaccine has remained elusive. Successful vaccination will require the immune system to function(More)
Themajor histocompatibility complex (MHC) is encoded by a set of genes that play a key role in the vertebrate adaptive immune system. In humans, these genes encode proteins termed human leukocyte antigens (HLAs). The corresponding expressed cell surface glycoproteins are divided into two classes: class I (MHC I) and II (MHC II). Although MHC I and MHC II(More)
Among the elderly, those at highest risk are the chronically ill, inactive patients. Assessing macronutrient requirements and outcome depends on longitudinal studies. Seven chronically ill, elderly female patients suffering from persistent infections, were studied monthly, over a 6-month period to determine their protein and energy requirements. Calorie and(More)
Functional analysis of T-cell responses in HIV-infected individuals has indicated that virus-specific CD8+ T cells with superior antiviral efficacy are well represented in HIV-1 controllers but are rare or absent in HIV-1 progressors. To define the role of individual T-cell receptor (TCR) clonotypes in differential antiviral CD8+ T-cell function, we(More)
A 2-year-old girl in whom a cardiac murmur had been detected at the age of 4 months underwent physical examination. She had no cyanosis, but a continuous murmur was detected. The murmur was centered in the 4th right intercostal space and radiated vertically. The echocardiogram showed right coronary artery (RCA) dilation. We sedated the patient and obtained(More)
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