Payanam R Umasankar

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Calcification is a frequent cause of the clinical failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated bovine pericardium (GATBP). Aspirin, a potent antiplatelet drug, and heparin, an anticoagulant, are commonly used for postimplant complications such as thrombosis and thromboembolism. Aspirin and heparin were embedded in(More)
BACKGROUND Valve-associated complications challenge the quality of life and longevity after heart valve replacement. Inappropriate healing may be a contributing factor. OBJECTIVE To evaluate a new design mechanical heart valve in an animal model. METHODS AND RESULTS The new valve was fabricated by substituting the sewing ring with an inbuilt suture(More)
The strength, resorption rates, and biocompatibility of collagenous biomaterials are profoundly influenced by the method of cross-linking. The in vitro and in vivo calcification and enzymatic degradation of bovine pericardia (BP) after a series of surface modifications were studied as a function of exposure time. Collagenase degradations of modified BP were(More)
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