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- Publications
- Influence
From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine.
- J. Zhu, Qian Wan, +7 authors S. Danishefsky
- Chemistry, Medicine
- Journal of the American Chemical Society
- 8 July 2009
A fully synthetic anticancer vaccine 2 has been prepared via bioconjugation of unimolecular pentavalent construct 1-containing five prostate and breast cancer associated carbohydrate antigens,… Expand
Design and synthesis of potent Quillaja saponin vaccine adjuvants.
- M. Adams, Payal Damani, +5 authors D. Gin
- Chemistry, Medicine
- Journal of the American Chemical Society
- 17 February 2010
The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that significantly enhances the immune response to a coadministered antigen. Only a handful of… Expand
Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.
- Kai Deng, M. Adams, Payal Damani, P. Livingston, G. Ragupathi, D. Gin
- Medicine
- Angewandte Chemie
- 11 August 2008
The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that is itself not necessarily immunogenic but significantly enhances the immune response of a… Expand
Synthesis and preclinical evaluation of QS-21 variants leading to simplified vaccine adjuvants and mechanistic probes.
- Eric K. Chea, Alberto Fernández-Tejada, +5 authors D. Gin
- Chemistry, Medicine
- Journal of the American Chemical Society
- 15 August 2012
QS-21 is a potent immunostimulatory saponin that is currently under clinical investigation as an adjuvant in various vaccines to treat infectious diseases, cancers, and cognitive disorders. Herein,… Expand
Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine
- G. Ragupathi, Payal Damani, +4 authors P. Livingston
- Biology, Medicine
- Cancer Immunology, Immunotherapy
- 4 February 2009
Sialyl Lewisa (sLea), also termed CA19-9 antigen, is recognized by murine mAb19-9 and is expressed on the cancer cell surface as a glycolipid and as an O-linked glycoprotein. It is highly expressed… Expand
Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins.
- G. Ragupathi, Payal Damani, +5 authors D. Gin
- Biology, Medicine
- Vaccine
- 11 June 2010
The saponin fraction QS-21 from Quillaja saponaria has been demonstrated to be a potent immunological adjuvant when mixed with keyhole limpet hemocyanin conjugate vaccines, as well as with other… Expand
Abstract 2417: Preclinical evaluation of potential novel synthetic saponin adjuvants with conjugate cancer vaccines
- G. Ragupathi, Payal Damani, N. R. Perl, A. Won, D. Gin, P. Livingston
- Medicine
- 15 April 2010
We have tested a variety of naturally isolated and synthetic carbohydrate and peptide cancer antigens conjugated to keyhole limpet hemocyanin (KLH) plus an immunological adjuvant in pre clinical… Expand