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Preclinical evaluation of the synthetic adjuvant SQS-21 and its constituent isomeric saponins.

• Govindaswami Ragupathi, Payal Damani, +5 authors David Y. Gin
• Vaccine
• 2010

The saponin fraction QS-21 from Quillaja saponaria has been demonstrated to be a potent immunological adjuvant when mixed with keyhole limpet hemocyanin conjugate vaccines, as well as with other… (More)

Synthesis of sialyl Lewisa (sLea, CA19-9) and construction of an immunogenic sLea vaccine

• Govindaswami Ragupathi, Payal Damani, +4 authors Philip O. Livingston
• Cancer Immunology, Immunotherapy
• 2008

Sialyl Lewisa (sLea), also termed CA19-9 antigen, is recognized by murine mAb19-9 and is expressed on the cancer cell surface as a glycolipid and as an O-linked glycoprotein. It is highly expressed… (More)

Design and synthesis of potent Quillaja saponin vaccine adjuvants.

• M. M. Adams, Payal Damani, +5 authors David Y. Gin
• Journal of the American Chemical Society
• 2010

The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that significantly enhances the immune response to a coadministered antigen. Only a handful of… (More)

Synthesis and preclinical evaluation of QS-21 variants leading to simplified vaccine adjuvants and mechanistic probes.

• Eric K. Chea, Alberto Fernández-Tejada, +5 authors David Y. Gin
• Journal of the American Chemical Society
• 2012

QS-21 is a potent immunostimulatory saponin that is currently under clinical investigation as an adjuvant in various vaccines to treat infectious diseases, cancers, and cognitive disorders. Herein,… (More)

Synthesis of QS-21-xylose: establishment of the immunopotentiating activity of synthetic QS-21 adjuvant with a melanoma vaccine.

• Kai Deng, M. M. Adams, Payal Damani, Philip O. Livingston, Govindaswami Ragupathi, David Y. Gin
• Angewandte Chemie
• 2008

The success of antitumor and antiviral vaccines often requires the use of an adjuvant, a substance that is itself not necessarily immunogenic but significantly enhances the immune response of a… (More)

From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine.

• Jianglong Zhu, Qian Wan, +7 authors Samuel J Danishefsky
• Journal of the American Chemical Society
• 2009

A fully synthetic anticancer vaccine 2 has been prepared via bioconjugation of unimolecular pentavalent construct 1-containing five prostate and breast cancer associated carbohydrate antigens,… (More)

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