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BACKGROUND In the past decade, catheter ablation has become an established therapy for symptomatic atrial fibrillation (AF). Until very recently, few data have been available to guide the clinical community on the outcomes of AF ablation at ≥3 years of follow-up. We aimed to systematically review the medical literature to evaluate the long-term outcomes of(More)
The Hilbert transform has been used to characterize wave propagation and detect phase singularities during cardiac fibrillation. Two mapping modalities have been used: optical mapping (used to map atria and ventricles) and contact electrode mapping (used only to map ventricles). Due to specific morphology of atrial electrograms, phase reconstruction of(More)
Using a dynamical model of smooth muscle cells in an arterial wall, defined as a system of coupled five-dimensional nonlinear oscillators, on a grid with cylindrical symmetry, we compare the admissible activity patterns with those known from the heart tissue. We postulate on numerical basis the possibility to induce a stable spiral wave in the arterial(More)
BACKGROUND Recently pericardial adipose tissue (PAT) has been shown to be an independent predictor of atrial fibrillation (AF). Atrial PAT may influence underlying atrial musculature creating a substrate for AF. This study sought to validate the assessment of total and atrial PAT by standard cardiovascular magnetic resonance (CMR) measures and describe and(More)
BACKGROUND Both ageing and hypertension are known risk factors for atrial fibrillation (AF) although the pathophysiological contribution or interaction of the individual factors remains poorly understood. Here we aim to delineate the arrhythmogenic atrial substrate in mature spontaneously hypertensive rats (SHR). METHODS SHR were studied at 12 and 15(More)
BACKGROUND Rotors are postulated to maintain cardiac fibrillation. Despite the importance of bipolar electrograms in clinical electrophysiology, few data exist on the properties of bipolar electrograms at rotor sites. The pivot of a spiral wave is characterized by relative uncertainty of wavefront propagation direction compared to the periphery. The bipolar(More)
Many conditions remodel the heart muscle such that it results in a perturbation of cells coupling. The effect of this perturbation on the stability of the spiral waves of electrochemical activity is not clear. We used the FitzHugh-Nagumo model of an excitable medium to model the conduction of the activation waves in a two-dimensional system with(More)
OBJECTIVE To explore technical challenges of phase singularity (PS) mapping during atrial fibrillation (AF) using direct contact electrograms. METHODS AF mapping was performed in high-density epicardial recordings of human paroxysmal (PAF) or persistent (PersAF) (N = 20 pts) AF with an array of 16 × 16 electrodes placed on atrial epicardium. PS points(More)
Unipolar electrogram can detect local as well as remote electrical activity of the heart. Information on how the amplitude and morphology of the recorded signal changes with the distance from the source tissue undergoing depolarization can help to better understand unipolar electrograms fractionation and provide insights into the passive conduction(More)
The aim of this study was to assess the reliability of the complexity analysis of single electrogram as an estimator of the length of the ablation procedure necessary for AF termination. Left and right atrial endocardial bipolar electrograms were recorded during ablation procedure of AF in 27 patients. Up to 30 second electrogram samples were measured at(More)