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BACKGROUND Ablation of long-standing persistent atrial fibrillation (AF) is highly variable, with differing techniques and outcomes. OBJECTIVE The purpose of this study was to undertake a systematic review of the literature with regard to the impact of ablation technique on the outcomes of long-standing persistent AF ablation. METHODS A systematic(More)
BACKGROUND There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described. OBJECTIVE To determine whether patients with OSA have an abnormal atrial substrate. METHODS Forty patients undergoing ablation of paroxysmal AF and in sinus rhythm (20 with OSA(More)
BACKGROUND In the past decade, catheter ablation has become an established therapy for symptomatic atrial fibrillation (AF). Until very recently, few data have been available to guide the clinical community on the outcomes of AF ablation at ≥3 years of follow-up. We aimed to systematically review the medical literature to evaluate the long-term outcomes of(More)
BACKGROUND Recently pericardial adipose tissue (PAT) has been shown to be an independent predictor of atrial fibrillation (AF). Atrial PAT may influence underlying atrial musculature creating a substrate for AF. This study sought to validate the assessment of total and atrial PAT by standard cardiovascular magnetic resonance (CMR) measures and describe and(More)
OBJECTIVES The purpose of this study was to determine whether patients with paroxysmal "lone" atrial fibrillation (AF) have an abnormal atrial substrate. BACKGROUND While "AF begets AF," prompt termination to prevent electrical remodeling does not prevent disease progression. METHODS Twenty-five patients with paroxysmal lone AF, without arrhythmia in(More)
OBJECTIVES The aim of this report was to study the effect of chronic stretch reversal on the electrophysiological characteristics of the atria in humans. BACKGROUND Atrial stretch is an important determinant for atrial fibrillation. Whether relief of stretch reverses the substrate predisposed to atrial fibrillation is unknown. METHODS Twenty-one(More)
BACKGROUND Hypertension accounts for more atrial fibrillation (AF) than any other predisposing factor. OBJECTIVE The purpose of this study was to characterize the time course, extent, and electrostructural correlation of atrial remodeling in chronic hypertension. METHODS Thirty-two sheep were studied: 21 with induced "one-kidney, one-clip" hypertension(More)
BACKGROUND It has been suggested that omega-3 polyunsaturated fatty acids (n-3 PUFAs) may prevent the development of atrial fibrillation (AF). OBJECTIVE The purpose of this study was to evaluate the impact of these agents on development of the AF substrate in heart failure (HF). METHODS In this study, HF was induced by intracoronary doxorubicin(More)
AIMS To characterize the atrial remodelling in mitral stenosis (MS). METHODS AND RESULTS Twenty-four patients with severe MS undergoing commissurotomy and 24 controls were studied. Electrophysiological evaluation was performed in 12 patients in each group by positioning multi-electrode catheters in both atria to determine the following: effective(More)
BACKGROUND Hypertension is frequently complicated by the development of atrial fibrillation (AF). However, the mechanisms of this link remain poorly understood. In addition, whether short-term hypertension can result in a substrate for AF is not known. OBJECTIVE The purpose of this study was to characterize the atrial substrate predisposing to AF due to(More)