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A population of the fire fighters who had been exposed to a natural disaster were screened using the General Health Questionnaire 4, 11, and 29 months after a natural disaster. On the basis of these data, a high-risk group of subjects who had scored as cases and probable cases and a symptom-free comparison group were interviewed using the Diagnostic(More)
Physical complaints are recognised accompaniments of Post-Traumatic Stress Disorder (PTSD). This study investigates the reporting of physical complaints in a treatment-naive sample of fire-fighters with and without PTSD. Statistically higher rates of cardiovascular, respiratory, musculoskeletal and neurological symptoms were reported in the PTSD group.(More)
BACKGROUND & AIMS Psoriasiform and eczematiform lesions are associated with anti-tumor necrosis factor (TNF)-α therapies. We assessed clinical characteristics, risk factors, and outcomes of skin disease in patients with inflammatory bowel diseases that presented with psoriasiform and eczematiform lesions induced by anti-TNF-α agents. METHODS We studied 85(More)
BACKGROUND We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced psoriasiform skin lesions in patients with inflammatory bowel diseases (IBD). DESIGN Patients with IBD were prospectively screened for anti-TNF-induced psoriasiform skin lesions. Patients were(More)
OBJECTIVES Fecal microbiota transplantation (FMT) from healthy donors, which is an effective alternative for treatment of Clostridium difficile-associated disease, is being considered for several disorders such as inflammatory bowel disease, irritable bowel syndrome, and metabolic syndrome. Disease remission upon FMT is thought to be facilitated by an(More)
Marcus Harbord,a,† Vito Annese,b Stephan R. Vavricka,c Matthieu Allez,d Manuel Barreiro-de Acosta,e Kirsten Muri Boberg,f,l Johan Burisch,g Martine De Vos,h Anne-Marie De Vries,i Andrew D. Dick,j Pascal Juillerat,k Tom H. Karlsen,f,l Ioannis Koutroubakis,m Peter L. Lakatos,n Tim Orchard,o Pavol Papay,p Tim Raine,q Max Reinshagen,r Diamant Thaci,s Herbert(More)
BACKGROUND Screening for latent tuberculosis (LTB) including chest x-ray, tuberculin skin test (TST), and facultative whole blood interferon-γ assay (IGRA) is part of routine management in inflammatory bowel disease (IBD) patients before starting therapy with tumor necrosis factor (TNF)-α inhibitors. However, in patients with immunomodulators (IM) TST and(More)
OBJECTIVES Smoking and a lack of immunosuppressive (IS) therapy are considered risk factors for intestinal surgery in Crohn's disease (CD). Good evidence for the latter is lacking. The objective of this study was to evaluate the impact of thiopurine treatment on surgical recurrence in patients after first intestinal resection for CD and its possible(More)
BACKGROUND IFN-γ release assays (IGRA), widely used for latent tuberculosis screening prior to anti-TNF-α treatment, are limited by indeterminate results in patients under immunomodulatory (IM) therapy. The aim of our observational study was to delineate factors associated with indeterminate IGRA results. METHODS A total of 190 patients with inflammatory(More)
Management of Crohn's disease has traditionally placed high value on subjective symptom assessment; however, it is increasingly appreciated that patient symptoms and objective parameters of inflammation can be disconnected. Therefore, strategies that objectively monitor inflammatory activity should be utilised throughout the disease course to optimise(More)