Pavol Novák

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Abnormal phosphorylation of tau protein represents one of the major candidate pathological mechanisms leading to Alzheimer's disease (AD) and related tauopathies. Altered phosphorylation status of neuronal tau protein may result from upregulation of tau-specific kinases or from inhibition of tau-specific phosphatases. Increased expression of the protein(More)
This study addresses involvement of major 5-fluorouracil (5-FU) pathway genes in the prognosis of colorectal carcinoma patients. Testing set and two validation sets comprising paired tumor and adjacent mucosa tissue samples from 151 patients were used for transcript profiling of 15 5-FU pathway genes by quantitative real-time PCR and DNA methylation(More)
This paper presents the FE formulation for which the only incompatibility is in the inter-element tractions. The boundary tractions and displacements are defined using the Betti's reciprocity, similarly as that used by BEM. As the integration for the stiffness matrix formulation is taken over the element boundaries only, the shape of matrix can be more(More)
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