Learn More
To avoid the main drawbacks of prolonged treatment with levodopa (involuntary movements and the "on-off" phenomenon), we administered apomorphine by mouth to 14 patients with Parkinson's disease. This treatment caused azotemia, which we circumvented by switching to N-propylnoraporpine, whose nephrotoxic dose (80 mg six times per day) was larger than its(More)
PAPAVASILIOU, P. S., S. T. MILLER, AND G. C. COTZIAS. Role of liver in regulating distribution and excretion of manganese. Am. J. Physiol. 2 I-I (I) : -2 I 1-2 16. I g66.-Rectal obstruction abolished the total-body loss of Mns4 in both manganese-loaded and jaundiced rats. Bile duct obstruction only diminished the excretion of the radioisotope, proving that(More)
Diphenylhydantoin (DPH) diminished the therapeutic effects of levodopa both in patients with parkinsonism and in patients with chronic manganese poisoning, as well as the levodopa-dependent dyskinesia for which the former were selected. In patients with Huntington chorea, it enhanced chorea and mental agitation and, thus, failed to conform with the(More)
The effects of seizures on the cerebral and peripheral metabolism of essential metals were studied in mice. Acute and chronic seizures were produced either by electroshock (ES) or by a systemic convulsant. Organ and subcellular distribution of 54Mn and 65Zn were determined prior to and at different intervals after seizure cessation. In mice shocked for 21(More)