Pavlina D. Konstantinova

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This paper compares two algorithms for Multiple Target Tracking (MTT), using Global Nearest Neighbor (GNN) and Suboptimal Nearest Neighbor (SNN) approach respectively. For both algorithms the observations are divided in clusters to reduce computational efforts. For each cluster the assignment problem is solved by using Munkres algorithm or according SNN(More)
RNA interference (RNAi) is a powerful approach to inhibit human immunodeficiency virus type 1 (HIV-1) replication. However, HIV-1 can escape from RNAi-mediated antiviral therapy by selection of mutations in the targeted sequence. To prevent viral escape, multiple small interfering RNAs (siRNAs) against conserved viral sequences should be combined. Ideally,(More)
In this paper we consider and analyze the behavior of two combinational rules for temporal/sequential attribute data fusion for target type estimation. Our comparative analysis is based on Dempster's fusion rule proposed in Dempster-Shafer theory (DST) and on the proportional conflict redistribution rule no. 5 (PCR5) recently proposed in Dezert-Smarandache(More)
– The objective of this paper is to present an approach for target tracking, which incorporates the advanced concept of generalized data (kinematics and attribute) association to improve track maintenance performance in complicated situations (closely spaced targets), when kinematics data are insufficient for correct decision making. It uses Global Nearest(More)
ABC transporters export clinically-relevant drugs and their over-expression causes multidrug resistance. In order to knock-down ABC transporters, ABCC1 and ABCC2, 13 shRNAs were developed. Four shRNA candidates were tested in vivo using self-complementary adeno-associated virus serotype 8. A strong, specific knock-down of Abbc2 was observed in mice liver,(More)
Overexpression of short hairpin RNA (shRNA) often causes cytotoxicity and using microRNA (miRNA) scaffolds can circumvent this problem. In this study, identically predicted small interfering RNA (siRNA) sequences targeting apolipoprotein B100 (siApoB) were embedded in shRNA (shApoB) or miRNA (miApoB) scaffolds and a direct comparison of the processing and(More)
RNA interference (RNAi) has been successfully employed for specific inhibition of gene expression; however, safety and delivery of RNAi remain critical issues. We investigated the combinatorial use of RNAi and U1 interference (U1i). U1i is a gene-silencing technique that acts on the pre-mRNA by preventing polyadenylation. RNAi and U1i have distinct(More)
In this paper, we present and compare different fusion rules which can be used for generalized data association (GDA) for multitarget tracking (MTT) in clutter. Most of tracking methods including target identification (ID) or attribute information are based on classical tracking algorithms as PDAF, JPDAF, MHT, IMM, etc and either on the Bayesian estimation(More)
Potent antiviral RNAi can be induced by intracellular expression of short hairpin RNAs (shRNAs) and artificial microRNAs (miRNAs). Expression of shRNA and miRNA results in target mRNA degradation (perfect base pairing) or translational repression (partial base pairing). Although efficient inhibition can be obtained, error-prone viruses such as human(More)
Recombination due to template switching during reverse transcription is a major source of genetic variability in retroviruses. In the present study we forced a recombination event in human immunodeficiency virus type 1 (HIV-1) by electroporation of T cells with DNA from a molecular HIV-1 clone that has a 300 bp long hairpin structure in the Nef gene(More)