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The release kinetics, antimicrobial activity and cytocompatibility of differently prepared collagen/hydroxyapatite/vancomycin layers: Microstructure vs. nanostructure
The results herein suggest that nano‐structured collagen‐hydroxyapatite layers impregnated with vancomycin following cross‐linking provide suitable candidates for use as local drug delivery carriers. Expand
The effects of different cross-linking conditions on collagen-based nanocomposite scaffolds-an in vitro evaluation using mesenchymal stem cells.
The genipin and EDC/NHS/PBS cross-linked scaffolds can be considered to be promising biomaterials for further in vivo testing and bone surgery applications. Expand
Hyaluronic acid as a modulator of the cytotoxic effects of cationic surfactants
Abstract CTAB (cetyltrimethylammonium bromide) and Septonex (carbethoxypendecinium bromide) are cationic surfactants known for harmful effects on different cell types (bacteria, fungi, mammal cells,Expand
Hyaluronic acid in complexes with surfactants: The efficient tool for reduction of the cytotoxic effect of surfactants on human cell types.
This comprehensive study of the effect of surfactant-HyA complexes on various human cell types revealed that HyA represents a useful CTAB or Septonex cytotoxic effect modulator at diverse levels. Expand
Initial cell adhesion of three cell types in the presence and absence of serum proteins
The study systematically describes and discusses the cell adhesion of three different human cell types to a well-known substrate without the presence of external proteins and it is hoped that this knowledge will be subsequently applied in biomaterial applications in which the presenceof external proteins is undesirable. Expand
Dry versus hydrated collagen scaffolds: are dry states representative of hydrated states?
The quantitative results provided confirm the importance of analysing scaffolds in the hydrated rather than the dry state since the former more precisely simulates the real environment for which such materials are designed. Expand
Evaluation of collagen/hydroxyapatite electrospun layers loaded with vancomycin, gentamicin and their combination: Comparison of release kinetics, antimicrobial activity and cytocompatibility.
This combination of vancomycin and gentamicin in the COL/HA layers exhibited sufficient cytocompatibility to SAOS-2, which was independent of the HA content and was found to be more effective against MRSA than is vancomYcin as a single agent. Expand
Comparison of ground sections, paraffin sections and micro-CT imaging of bone from the epiphysis of the porcine femur for morphometric evaluation.
Histomorphometric studies based on relatively low numbers of undecalcified ground sections or demineralized paraffin sections of bone yield data on bone volume and the thickness of cortical compact bone that is comparable with three-dimensional micro-CT examination. Expand
Positive impact of dynamic seeding of mesenchymal stem cells on bone-like biodegradable scaffolds with increased content of calcium phosphate nanoparticles
Results showed the used dynamic colonization technique together with the newly-developed collagen-based scaffold with high content of bCaP to be an effective combined tool for producing bone grafts for bone implantology and regenerative medicine. Expand
Influence of Cell-Penetrating Peptides on the Activity and Stability of Virus-Based Nanoparticles.
The findings indicate that peptides acting as transduction-enhancing agents of polyomavirus-based nanoparticles modulate their physical state, which can be an important prerequisite for sensitization of cells and determination of the further fate of viral particles inside cells. Expand