Pavitra Singh

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are being administered increasingly by transdermal drug delivery for the treatment of local muscle inflammation. The human epidermal permeabilities of different NSAIDs (salicylic acid, diethylamine salicylate, indomethacin, naproxen, diclofenac and piroxicam) from aqueous solutions is dependent on the drug's(More)
The depth of penetration of solutes into underlying tissues after transdermal iontophoresis has been evaluated with salicylic acid and lidocaine as model compounds. Concentrations of salicylic acid and lidocaine were measured in plasma and tissues below the donor electrode after iontophoresis in rats. The concentrations obtained were then compared with(More)
Topically applied compounds can penetrate directly into deeper underlying tissues. In this report, an attempt has been made to establish structure-deep tissue penetration relationships for a variety of solutes with diverse physicochemical properties. Stepwise multiple linear regression analysis was performed with the concentration in the immediately(More)
The effects of the local vasoconstrictor phenylephrine on the dermal absorption kinetics and local tissue distribution of compounds were investigated in rats. Phenylephrine (0.0025% -0.1%) and tracer quantities of salicylic acid, lidocaine, and water were applied in an aqueous solution to the exposed rat dermis. The disappearance of salicylic acid from the(More)
The local deep tissue penetration of bases such as diazepam, antipyrine, iodoantipyrine, haloperidol and steroids such as hydrocortisone, fluocinolone acetonide, testosterone and progesterone after dermal application as aqueous solutions was studied in a rat model. The extent of local, as distinct from systemic delivery, for each solute was assessed by(More)
The deep-tissue penetration of lidocaine below a dermally applied site was quantified in a rat model. The concentrations of lidocaine in tissues below the applied site were measured and compared with plasma concentrations and concentrations in similar tissues on the contralateral side. The direct penetration of lidocaine was predominant for the first 2 h up(More)
Blood flow rates to skin and underlying tissues in rats were determined by the radioactive microsphere technique. The dermal and local tissue clearance of two polar solutes, tritiated water and 14C-labeled sucrose, was assessed in anesthetized and sacrificed rats. The dermal clearance of tritiated water in the presence of viable dermal blood supply (6.17(More)
Endemic fluorosis was detected in 31 villages in the Dhar district of Madhya Pradesh, Central India. Out of the 109 drinking water sources that were analyzed, about 67 % were found to contain high concentration of fluoride above the permissible level of 1.0 mg/l. Dental fluorosis among the primary school children in the age between 8 and 15 served as(More)
A specific extracorporeal immunoadsorbent system has been developed that has potential application for the treatment of complications related to the presence of plasma insulin antibodies, namely severe insulin resistance and autoimmune hypoglycemia. The immunoadsorbent system described here makes use of a commercially available cellulose-based, hollow-fiber(More)
The rate of generation of household solid waste in the developing countries is increasing with an increase of population, technological development, and the changes in the life styles of the people which is posing a great environmental and public health problem. As family size and income are the most significant factors affecting the quantity of solid waste(More)
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