Pavithra Viswanath

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Repositioning of existing drugs has been suggested as a fast track for developing new anti-malarial agents. The compound libraries of GlaxoSmithKline (GSK), Pfizer and AstraZeneca (AZ) comprising drugs that have undergone clinical studies in other therapeutic areas, but not achieved approval, and a set of US Food and Drug Administration (FDA)-approved drugs(More)
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The(More)
Whole-cell high-throughput screening of the AstraZeneca compound library against the asexual blood stage of Plasmodium falciparum (Pf) led to the identification of amino imidazoles, a robust starting point for initiating a hit-to-lead medicinal chemistry effort. Structure-activity relationship studies followed by pharmacokinetics optimization resulted in(More)
Thiocyanate (SCN(-)) is a highly chaotropic anion of considerable biological significance, which interacts quite strongly with lipid interfaces. In most cases it is not exactly known if this interaction involves direct binding to lipid groups, or some type of indirect association or partitioning. Since thiocyanate is a linear ion, with a considerable dipole(More)
We report our studies on the mixed Langmuir monolayer of mesogenic molecules, p-(ethoxy)-p-phenylazo phenyl hexanoate (EPPH) and octyl cyano biphenyl (8CB), employing the techniques of surface manometry and Brewster angle microscopy. Our studies show that the mixed monolayer exhibits higher collapse pressures for certain mole fractions of EPPH in 8CB as(More)
We report experimental results on the formation, dynamics, and annihilation of edge dislocations of opposite topological charge in the electroconvective inplane vortex state of a bent core nematic liquid crystal. The approach of paired, oppositely charged defects toward each other is a two-step process. Near constant velocity at large separation and(More)
We report the interactions of a mesogenic molecule, 4'-octyl-4-biphenyl-carbonitrile (8CB), with some cations (Na(+), Cu(2+), Ni(2+), La(3+) and Al(3+)) dissolved in the aqueous subphase. Surface manometry studies show that the di- (Ni(2+) and Cu(2+)) and trivalent (La(3+)) ions promote condensation in the area per molecule and enhance the stability of the(More)
We have investigated the miscibility in the mixed monolayers of cholesterol (Ch)-octyl cyano biphenyl (8CB) and cholesteryl acetate (ChA)-8CB using surface manometry and epifluorescence microscopic techniques. The main skeleton is the same both in Ch and ChA, whereas the polar head group is alcohol in Ch and ester in ChA. The 8CB molecule has a polar cyano(More)
The pace of anti-malarial drug discovery is often impeded due to the lack of tools to determine the cidality of compounds in vitro. An anti-malarial compound must have a cidal mode of action, i.e. kill parasites, in order to quickly reduce parasite load. A static compound that merely inhibits growth must be identified early on in the discovery cascade. In(More)
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