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  • Miloš Hroch, Stanislav Micuda, Jolana Cermanová, Jaroslav Chládek, Pavel Tomšík
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 1 October 2013
  • Boldine belongs to the group of aporphine alkaloids isolated from Boldo tree. In contrast with numerous reports on the pharmacological effects of boldine, the data about its pharmacokinetics andContinue Reading
  • Mohamed Abou Niang, Milan Mělka, Alena Stoklasová, Jaroslav Cerman, Pavel Tomšík
  • Medicine
  • Pharmacological research
  • 1 December 2006
  • We have commenced a series of experiments to evaluate the effect of carnitine derivatives on the antineoplastic activity of mitoxantrone (MX) on various animal cancers. This report describes theContinue Reading
  • Lenka Suchá, Miloš Hroch, +7 authors Pavel Tomšík
  • Medicine, Biology
  • Oncology reports
  • 1 December 2013
  • In recent years, α-tomatine has been studied for its anticancer activity. In the present study, we focused on the cytotoxic effect of α-tomatine in the MCF-7 human breast adenocarcinoma cell line,Continue Reading
    BACKGROUND The limitation of carbonyl reduction represents one possible way to increase the effectiveness of anthracycline doxorubicin (DOX) in cancer cells and decrease its toxicity in normal cells.Continue Reading