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The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens.

• Pavel Tolar, Joseph Hanna, Peter D. Krueger, Susan K Pierce
• Immunity
• 2009

B cells are activated in vivo after the B cell receptors (BCRs) bind to antigens captured on the surfaces of antigen-presenting cells. Antigen binding results in BCR microclustering and signaling;… (More)

Antigen affinity discrimination is an intrinsic function of the B cell receptor

• Wanli Liu, Tobias Meckel, Pavel Tolar, Hae Won Sohn, Susan K Pierce
• The Journal of experimental medicine
• 2010

Antibody affinity maturation, a hallmark of adaptive immune responses, results from the selection of B cells expressing somatically hypermutated B cell receptors (BCRs) with increased affinity for… (More)

The initiation of antigen-induced B cell antigen receptor signaling viewed in living cells by fluorescence resonance energy transfer

• Pavel Tolar, Hae Won Sohn, Susan K Pierce
• Nature Immunology
• 2005

Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ultimately leads to B cell activation. Using quantitative fluorescence resonance energy transfer imaging, we provide… (More)

Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling.

• Wanli Liu, Tobias Meckel, Pavel Tolar, Hae Won Sohn, Susan K Pierce
• Immunity
• 2010

Memory B cells express high-affinity, immunoglobulin GB cell receptors (IgG BCRs) that enhance B cell responses, giving rise to the rapid production of high-affinity, IgG antibodies. Despite the… (More)

Membrane heterogeneities in the formation of B cell receptor–Lyn kinase microclusters and the immune synapse

• Hae Won Sohn, Pavel Tolar, Susan K Pierce
• The Journal of cell biology
• 2008

Antigen binding to the B cell receptors (BCRs) induces BCR clustering, phosphorylation of BCRs by the Src family kinase Lyn, initiation of signaling, and formation of an immune synapse. We… (More)

The molecular assembly and organization of signaling active B-cell receptor oligomers.

• Pavel Tolar, Hae Won Sohn, Wanli Liu, Susan K Pierce
• Immunological reviews
• 2009

In B cells, antigen drives the formation of B-cell receptor (BCR) clusters that initiate the formation of signaling complexes associated with the cytoplasmic domains of the BCRs. These signaling… (More)

Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling.

• Hae Won Sohn, Pavel Tolar, Tian Jiao Jin, Susan K Pierce
• Proceedings of the National Academy of Sciences…
• 2006

B cell responses are initiated by the clustering of the B cell receptor (BCR) by the binding of multivalent antigens. Clustering leads to phosphorylation of tyrosines in the cytoplasmic domains of… (More)

Structure-Function Analysis of Lyn Kinase Association with Lipid Rafts and Initiation of Early Signaling Events after Fcɛ Receptor I Aggregation

• Martina Kovářová, Pavel Tolar, Ramachandran Arudchandran, Lubica Draberova, Juan Felipe Rivera, Petr Dráber
• 2001

B cell antigen extraction is regulated by physical properties of antigen-presenting cells

• Katelyn M Spillane, Pavel Tolar
• The Journal of cell biology
• 2017

Antibody production and affinity maturation are driven by B cell extraction and internalization of antigen from immune synapses. However, the extraction mechanism remains poorly understood. Here we… (More)

Antigen-induced oligomerization of the B cell receptor is an early target of Fc gamma RIIB inhibition.

• Wanli Liu, Hae Won Sohn, Pavel Tolar, Tobias Meckel, Susan K Pierce
• Journal of immunology
• 2010

The FcgammaRIIB is a potent inhibitory coreceptor that blocks BCR signaling in response to immune complexes and, as such, plays a decisive role in regulating Ab responses. The recent application of… (More)

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