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- R Eric Davis, Vu Ngo, +34 authors Louis M. Staudt
- Nature
- 2010
A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineering mouse models, but genetic and functional… (More)
- Pavel Tolar, Joseph Hanna, Peter Krueger, Susan K Pierce
- Immunity
- 2009
B cells are activated in vivo after the B cell receptors (BCRs) bind to antigens captured on the surfaces of antigen-presenting cells. Antigen binding results in BCR microclustering and signaling;… (More)
- Pavel Tolar, Hae Won Sohn, Susan K Pierce
- Nature Immunology
- 2005
Binding of antigen to the B cell antigen receptor (BCR) triggers signaling that ultimately leads to B cell activation. Using quantitative fluorescence resonance energy transfer imaging, we provide… (More)
- Milena Kovářová, Pavel Tolar, Ramachandran Arudchandran, L'ubica Dráberová, J. Rivera, Pavel Dráber
- Molecular and cellular biology
- 2001
The first step in immunoreceptor signaling is represented by ligand-dependent receptor aggregation, followed by receptor phosphorylation mediated by tyrosine kinases of the Src family. Recently,… (More)
- Hae Won Sohn, Pavel Tolar, Susan K Pierce
- The Journal of cell biology
- 2008
Antigen binding to the B cell receptors (BCRs) induces BCR clustering, phosphorylation of BCRs by the Src family kinase Lyn, initiation of signaling, and formation of an immune synapse. We… (More)
- Sergei Radaev, Zhongcheng Zou, +6 authors P. Sun
- Structure
- 2010
The B cell antigen receptor (BCR) plays an essential role in all phases of B cell development. Here we show that the extracellular domains of murine and human Igbeta form an I-set immunoglobulin-like… (More)
- Wanli Liu, Tobias Meckel, Pavel Tolar, Hae Won Sohn, Susan K Pierce
- The Journal of experimental medicine
- 2010
Antibody affinity maturation, a hallmark of adaptive immune responses, results from the selection of B cells expressing somatically hypermutated B cell receptors (BCRs) with increased affinity for… (More)
- Hae Won Sohn, Pavel Tolar, Tian Jin, Susan K Pierce
- Proceedings of the National Academy of Sciences…
- 2006
B cell responses are initiated by the clustering of the B cell receptor (BCR) by the binding of multivalent antigens. Clustering leads to phosphorylation of tyrosines in the cytoplasmic domains of… (More)
The generation of high-affinity antibodies depends on the ability of B cells to extract antigens from the surfaces of antigen-presenting cells. B cells that express high-affinity B cell receptors… (More)
- Carla R. Nowosad, Katelyn M Spillane, Pavel Tolar
- Nature Immunology
- 2016
B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen internalization in immune synapses. Using large-scale imaging across B cell subsets, we found that, in contrast… (More)