Pavel Chelidze

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The size and number of fibrillar centers (FCs) was shown to be proportional to or correlate with the ploidy of the cell, respectively. In the active nucleoli of erythroblasts, the numbers of FCs exceeds several-fold that of nucleoli organizing regions (NORs). In the course of maturation, the number of FCs becomes 3-10 times lower than that of NORs. The(More)
A study was made of the fine structure of the light zone (fibrillar centres) that appear in the interphase nucleoli of PEK cell culture after the action of actinomycin D. The fibrillar centres contain densely packed homogeneous fibrils whose diameter ranged between 7-10 nm. Analysis of serial sections suggests that fibrillar centres may represent spherical(More)
We studied the ultrastructure of lymphocyte nucleoli from rat peripheral blood within the first 6 hrs of their cultivation in the presence of phytohaemagglutinin (PHA). In the mixed population of intact lymphocytes there were observed several types of nucleoli, the localization and the ratio of individual nucleolar components being different. This seems to(More)
The work presents the results of investigating the DNA synthesis in hepatic cell nuclei of mice as well as changes in the ultrastructure of hepatocytes nuclei of the rat after injections of nucleic fraction of the liver homogenate. The obtained data clearly suggest that reparation of the amount of DNA in the nuclei of hepatocytes of mice after a decrease of(More)
A study was made of the nucleolar vacuoles in guinea pig hepatocytes that are poorly investigated for animal cells. A comparison of ultrathin sections, contrasted by heavy metals, with those treated according to Bernhard allowed to reveal the following intravacuolar structures: 1) fibrils 10-15 nm and 20-30 nm thick similar to perinucleolar chromatin(More)
245 A Doctor of Science, Professor, Honored Scientist, Corresponding Member of the Georgian Academy of Sciences, for many years he was an active and important member of the informal scientific community integrating scientists of the Soviet Union working in developmental biology. As before, the community activity was tightly linked to the Kol’tzov Institute(More)
Ultrastructural 3-D analysis of nucleolar architecture and Ag-NOR protein distribution in mouse kidney-cortex proximal-tubule epithelium has been performed. A principal scheme of structural changes of the nucleolus and organization of its components during the intensification of pre-rRNA synthesis (dynamic model of a nucleolus) based on computer spatial(More)
The transformation of nucleolus and its structural components in the main groups of erythroid cells (from pronormoblasts to reticulocytes and dividing ones) has been studied. It is shown that during inactivation of the nucleolus, the granular component is reduced, and the degree of chromatin condensation increases. Enlargement and "naking" of fibrillar(More)
The number and volume of fibrillar centres, the structural components of interphase cell nucleoli on the surface of which rRNA is synthesized, have been studied in differentiating erythroblasts of mouse embryo liver. Complete series of ultrathin sections of erythroblast nuclei have been used at the main stages of differentiation: proerythroblast, basophilic(More)
By means of stereological and morphological analysis, the dynamics of nucleolar structural changes in stimulated mouse hepatocytes has been studied. Reticulated and vacuolized nucleoli typical for normally functioning hepatocytes were shown to convert into the nucleolonemal nucleoli, first noticed 18 hours following operation. The process of activation of(More)