Pavel A. Dyban

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The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors responsible for the maintenance of the undifferentiated state of multipotent TS cells. Here we report the(More)
Epigenetic reprogramming implies changes in germ and somatic cells of an embryo, which are the consequences of gene activity regulation by means of DNA methylation, histone modification, and altered chromatin compaction. This suggests that epigenetic changes in mammalian cell nucleus occur during gametogenesis and totipotent zygote formation. Epigenetic(More)
A characteristic feature of systemic autoimmune diseases, along with the appearance of autoantibodies that target self-antigenes, is the deposition of immunoglobulins and components of the complementary system in kidneys. However, the process of the development of a deposit and its cytotoxic effects still remain poorly studied. To elucidate these questions,(More)
The rat represents very important, superior in many respects to the mous, animal model for studying pharmacology, physiology, ageing, cardiovascular etc. However, numerous attempts to derive rat ES cells necessary to carry out loss-of-gene-function studies have not been successful thus far. Therefore rat induct pluripotent stem cells (or riPS) should(More)
A comparison of the number of follicular epithelium cells and its proliferative activity with the oocyte diameter upon normal (ICR mice) and abnormal (LT/Sv mice) oogenesis was carried out. Two populations of monolayered follicles were found in the LT/Sv mice. The population of normal follicles providing for reproductive function is characterized by a(More)
The p a r a m e t e r s of the mitot ic cycle of the gall b ladder epithelial cel ls and the pa t t e rn of mucus format ion were de te rmined autoradiographical ly . The bases of the epithelial folds a re cambial , but their apex consis ts of m o r e highly different iated zones. Since the pro l i f e ra t ive pool of epithelial cells of the guinea pig(More)
The appearance of G2-chalone in the cytoplasm of the intermediate cell layer and partly in the periderm of 17-day-old rat embryo epidermis has been demonstrated by the indirect method of Coons using a monospecific antiserum. G2-chalone was absent from the basal cell layer of 17--21-day-old embryos and of the newborn rats. It was found in all the epidermal(More)
Autoradiography has demonstrated that a single injection of hydrocortisone (10mg/100 gm b.w.) reduced statistically significant the number of DNA synthesizing cells and the intensity of 3H-thymidine incorporation in these cells, as well as reduced the number of mitotically dividing epithelial cells in the rat ureter. 16 hours after hydrocortisone(More)