Paulw Noble

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The effect of a Ring A-reduced metabolite of corticosterone, 5 alpha-dihydrocorticosterone (DHB) on long-term potentiation (LTP) in the dentate gyrus (DG) of the rat were studied in barbiturate-anaesthetised animals. It was observed that DHB significantly impairs the development of LTP, more particularly the population spike (PS) component of the evoked(More)
Metabolism of catecholamines can generate reactive free radical species, including hydrogen peroxide (H2O2), that are potentially harmful to cells. In this study, norepinephrine (NE) and epinephrine (EPI) were found to be toxic to oligodendrocyte (OL) cultures derived from adult rat brain. The catecholamine toxicity, reproduced by equimolar concentrations(More)
The extension of cellular processes from the oligodendrocyte soma is an early and critical event in myelin formation. Previous reports from this laboratory have implicated a role for protein kinase C (PKC) as an important intracellular mediator of this critical step in myelinogenesis. In the current study, the regrowth of fibers by adult human(More)
Macrophages play an important role in the acute tissue inflammatory response through the release of cytokines and growth factors in response to stimuli such as lipopolysaccharide (LPS). Macrophage inflammatory effector functions are also influenced by interactions with the extra-cellular matrix (ECM). Such macrophage-ECM interactions may be important in(More)
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