Paulo Cesar Felix Osorio

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Bilateral adrenocortical hyperplasia (BAH) is the second most common cause of corticotropin-independent Cushing syndrome (CS). Genetic forms of BAH have been associated with complex syndromes such as Carney Complex and McCune–Albright syndrome or may present as isolated micronodular adrenocortical disease (iMAD) usually in children and young adults with CS.(More)
Inactivating germline mutations in phosphodiesterase 11A (PDE11A) have been implicated in adrenal tumor susceptibility. PDE11A is highly expressed in endocrine steroidogenic tissues, especially the testis, and mice with inactivated Pde11a exhibit male infertility, a known testicular germ cell tumor (TGCT) risk factor. We sequenced the PDE11A gene-coding(More)
The diagnosis of coronary artery disease in women has been thought to be more difficult than in men, owing to the lower overall prevalence of disease in women, as well as more subtle clinical presentations and unspecific changes in ST segment. The authors report a clinical case of a 61-year old woman, with low cardiovascular risk and history of atypical(More)
The authors present a clinical case of coronary spasm in acute myocardial infarction in a 22-year-old patient, admitted to the emergency department with chest pain. Angiography revealed normal coronary arteries and during the procedure a coronary spasm occurred.
OBJECTIVE To image the thoracic aorta by transesophageal echocardiography (TEE) and study atherosis (morphology and extent of atheroma plaques) and sclerosis (stiffness) and secondarily correlate them with serum lipid levels (cholesterol, HDL, LDL and triglycerides). METHODS We studied 29 patients (pts) who underwent TEE electively (male 18 pts, age 57.8(More)
In a competitive business environment, the use of project management can allow organizations to strategically structure themselves to achieve their business goals and needs. In this way, organizations can invest in more effective project management that is aimed at achieving better performance, maximizing the possibility of success, and minimizing the(More)
INTRODUCTION About 30% of all patients do not respond to cardiac resynchronization therapy for heart failure. The objective of the study was to analyze the variables that may predict the lack of response. PATIENTS AND METHOD We analyzed the results in a series of 63 patients who received cardiac resynchronization with a biventricular device. Clinical and(More)