Paulino Gómez-Puertas

Eduardo López-Viñas3
Ana Barbas2
Elizabeth Valdivieso2
Teresa Gárate2
3Eduardo López-Viñas
2Ana Barbas
2Elizabeth Valdivieso
2Teresa Gárate
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Reversible protein phosphorylation is one of the most important forms of cellular regulation. Thus, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool to evaluate cell functional status. The importance of protein kinase-regulated signal transduction pathways in human cancer has led to the development of drugs that inhibit(More)
Cadherins form a large family of calcium-dependent cell-cell adhesion receptors involved in development, morphogenesis, synaptogenesis, differentiation, and carcinogenesis through signal mechanotransduction using an adaptor complex that connects them to the cytoskeleton. However, the molecular mechanisms underlying mechanotransduction through cadherins(More)
  • Filipa P. Reis, Ana Barbas, A. A. Klauer-King, Borislava Tsanova, Daneen Schaeffer, Eduardo López-Viñas +3 others
  • 2013
In eukaryotes, the exosome plays a central role in RNA maturation, turnover, and quality control. In Saccharomyces cerevisiae, the core exosome is composed of nine catalytically inactive subunits constituting a ring structure and the active nuclease Rrp44, also known as Dis3. Rrp44 is a member of the ribonuclease II superfamily of exoribonucleases which(More)
Eukaryotic cells respond to DNA damage by activating damage checkpoint pathways, which arrest cell cycle progression and induce gene expression. We isolated a full-length cDNA encoding a 49-kDa protein from Leishmania major, which exhibited significant deduced amino acid sequence homology with the annotated Leishmania sp. DNA damage-inducible (Ddi1-like)(More)
UNLABELLED From conformational studies to atomistic descriptions of enzymatic reactions, potential and free energy landscapes can be used to describe biomolecular systems in detail. However, extracting the relevant data of complex 3D energy surfaces can sometimes be laborious. In this article, we present MEPSA (Minimum Energy Path Surface Analysis), a(More)
  • Elizabeth Valdivieso, Maria J. Perteguer, Carolina Hurtado, Pamela Campioli, Esperanza Rodríguez, Ana Saborido +4 others
  • 2015
Serine proteinase inhibitors (serpins) finely regulate serine proteinase activity via a suicide substrate-like inhibitory mechanism. In parasitic nematodes, some serpins interact with host physiological processes; however, little is known about these essential molecules in Anisakis. This article reports the gene sequencing, cloning, expression and(More)
  • Filipa P. Reis, Ana Barbas, A. A. Klauer-King, Borislava Tsanova, Daneen Schaeffer, Eduardo López-Viñas +3 others
  • 2015
There are errors in the Funding section. The correct funding information is as follows: F.P.R. was a recipient of a Fundação para a Ciência e a Tecnologia (FCT) Ph.D. fellowship and A.B. was a recipient of a FCT PostDoc. fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.(More)
  • María Arnedo, Sebastián Menao, Beatriz Puisac, María E. Teresa-Rodrigo, María C. Gil-Rodríguez, Eduardo López-Viñas +5 others
  • 2012
A novel lyase activity enzyme is characterized for the first time: HMG-CoA lyase-like1 (er-cHL), which is a close homolog of mitochondrial HMG-CoA lyase (mHL). Initial data show that there are nine mature transcripts for the novel gene HMGCLL1, although none of them has all its exons. The most abundant transcript is called "variant b," and it lacks exons 2(More)
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