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AIMS Heme derived from hemolysis is pro-oxidative and proinflammatory and promotes vaso-occlusion in murine models of sickle cell disease (SCD), suggesting that enhanced detoxification of heme may be… Continue Reading
PURPOSE To report the performance of various contact lenses and lens care solution combinations based on the combined response of subjective comfort and adverse events (AEs). METHODS A… Continue Reading
PURPOSE To investigate the mechanism underlying hyperopic orthokeratology (OK) by comparing the short-term clinical effect of lenses before and after central lens fenestration. METHODS Twelve… Continue Reading
Patients with sickle cell disease have unrelenting hemolysis leading to the release of hemoglobin and heme into the vasculature that promote oxidative stress, inflammation, vaso-occlusive pain… Continue Reading
Dithiolethione compounds, such as the well-characterized chemotherapeutic oltipraz, possess chemopreventive, cytoprotective, anti-angiogenic, and chemotherapeutic properties. The chemopreventive ef...