Pauline Schroeder

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Deletions within the mitochondrial DNA (mtDNA) are thought to contribute to extrinsic skin aging. To study the translation of mtDNA deletions into functional and structural changes in the skin, we seeded human skin fibroblasts into collagen gels to generate dermal equivalents. These cells were either derived from Kearns-Sayre syndrome (KSS) patients, who(More)
Trichloroacetic acid (TCA, CCl(3)COOH) has been associated with forest damage but the source of TCA to trees is poorly characterised. To investigate the routes and effects of TCA uptake in conifers, 120 Sitka spruce (Picea sitchensis (Bong.) Carr) saplings were exposed to control, 10 or 100 microg l(-1) solutions of TCA applied twice weekly to foliage only(More)
Tamoxifen has found extensive use in the treatment of all stages of human breast cancer. The efficacy of tamoxifen treatment for the pre vention of second primary tumors and Its chemosuppressive action In animal models have led to Initiation ofclinical trials to test its emeacy for prevention of this disease In women. Recently, tamoxifen has been shown to(More)
Until now the susceptibility of human skin to detrimental effects of solar radiation (e.g. photoaging) has mostly been assigned to the type of radiation and to the skin type. We have raised the question whether the circadian rhythm plays a role in the susceptibility of human dermal fibrob-lasts (HDF) to IRA (760–1440 nm). IRA accounts for one third of the(More)
Aged tissues contain increased levels of large-scale deletions of the mitochondrial (mt) DNA. Especially extrinsi-cally aged skin has been shown to carry a significant burden of mtDNA deletions along with several other structural and functional impairments. Until now the functional role of mtDNA mutations for functional and structural changes of aged skin(More)
Numerous diseases share common pathways with aging processes. Therefore, it is important to understand the mechanisms of aging and senescence on a cellular level. Environmental stressors such as sun light and diet are known to induce oxidative stress and advance aging processes. Mitochondrial and nuclear dysfunction and increased oxidative stress contribute(More)
Infrared-A radiation (IRA; 760–1440 nm), a major component of natural sunlight, accounts for one third of the energy reaching human skin. We have shown in previous studies that IRA irradiation of human dermal fibroblasts (HDF) leads to an increase in expression of matrix metal-loproteinase 1 (MMP-1) via an increase in mitochondrial reactive oxygen species(More)
Vascular diseases are associated with cellular aging, which is accompanied by telomere shortening counteracted in the nucleus by telomerase reverse transcriptase (TERT). Under conditions of oxidative stress TERT is exported from the nucleus and this export is mediated by Src-kinases via tyrosine phosphorylation of TERT. Nuclear export of TERT resulted in(More)
Infrared A radiation (IRA 760–1440 nm), a major component of solar radiation reaching the human skin, has been shown to alter the expression of matrixmetalloproteinase-1 (MMP-1) in human dermal fibroblasts involving retro-grade mitochondrial signaling pathways. Aim of this study was to examine the gene regulatory potential of IRA beyond MMP-1, the role of(More)
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