Pauline Marche

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BACKGROUND Human endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients. OBJECTIVE AND METHODS We analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear(More)
The aim of the study is to investigate the potential of a feedforward neural network for detecting wavelet preprocessed late potentials. The terminal parts of a simulated QRS complex are processed with a continuous wavelet transform, which leads to a time-frequency representation of the QRS complex. Then, diagnostic feature vectors are obtained by(More)
Speckle noise is known to be signal-dependent in ultrasound imaging. Hence, separating noise from signal becomes a difficult task. This paper describes a wavelet-based method for reducing speckle noise. We derive from the model of the displayed ultrasound image the optimal wavelet-domain filter in the least mean-square sense. Simulations on synthetic data(More)
An echographic image processing method has been developed, and validated by in vitro experiments, for the 3D reconstruction of the long bones of the newborn. The reconstruction of successive parallel cross-sections is obtained by a 2D reconstruction technique using radial B-scan image processing. The automatic segmentation of all the calculated images(More)
At the early stage of treatment, IFN alpha-2a induces inhibition of HCV replication. The viral load reflects mainly the degradation rate of the viruses. However, differences in the behavior of the viral population depend on changes, which occurred in the HCV-IRES genome. In this study, cloning and sequencing strategies permitted the generation of a large(More)
Microvascular dysfunction may have an early onset in type 1 diabetes (T1D) and can precede major complications. Our objectives were to assess the endothelial-dependent (acetylcholine, ACh; and post-occlusive hyperemia, PORH), non-endothelial-dependent (sodium nitroprusside, SNP) and neurovascular-dependent (local heating, LH and current induced(More)
Laser speckle contrast imaging (LSCI) is a full-field imaging modality to monitor microvascular blood flow. It is able to give images with high temporal and spatial resolutions. However, when the skin is studied, the interpretation of the bidimensional data may be difficult. This is why an averaging of the perfusion values in regions of interest is often(More)
An optimal wavelet filter to improve the signal-to-noise ratio (SNR) of the signal-averaged electrocardiogram is described. As the averaging technique leads to the best unbiased estimator, the challenge is to attenuate the noise while preserving the low amplitude signals that are usually embedded in it. An optimal, in the mean-square sense, wavelet-based(More)
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