Pauline Levinson

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Cell proliferation in Drosophila imaginal discs appears to be regulated by a disc-intrinsic mechanism involving local cell interactions that also control the formation of patterns of differentiation. This growth-control mechanism breaks down in animals homozygous for the mutation lethal (2) giant discs (l(2)gd) which remain as larvae for up to 9 days longer(More)
BACKGROUND Several mucosal innate immune proteins exhibit HIV inhibitory activity and their analogues are potential microbicide candidates. However, their clinical associations and in-vivo role in cervicovaginal host defense against HIV acquisition are poorly defined. METHODS Cervicovaginal secretions (CVSs) were collected from HIV uninfected Kenyan sex(More)
OBJECTIVES Globally, heterosexual intercourse is the primary route of HIV-1 (HIV) transmission. It follows that mechanisms that protect against HIV infection are likely operative at the genital mucosa. In HIV-resistant Kenyan sex workers who are highly exposed to HIV infection yet remain uninfected, protection correlates with HIV-specific immune responses(More)
D liver injury (DILI) remains the most frequent single cause of drug withdrawals and is difficult to detect at an early stage. For many drugs, hepatotoxic effects are observed in the range of 1 in 10 000 patients or fewer. Drug-induced liver injury may be caused by several different mechanisms, and it is often difficult to establish a clear causal(More)
OBJECTIVE Cervicovaginal HIV-1-neutralizing immunoglobulin A (IgA) was associated with reduced HIV-1 acquisition in a cohort of commercial sex workers. We aimed to define the prevalence and correlates of HIV-1-neutralizing IgA from HIV-1-exposed seronegative (HESN) women in HIV-1-serodiscordant relationships. METHODS HIV-1-serodiscordant couples in(More)
Recently, the current authors reported the presence in normotensive male and female urines of reproducibly measurable levels of naturally occurring substances in partially purified extracts of urine with inhibitory activity like glycyrrhetic acid (GA) towards both 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) and steroid 5 beta-reductase (5 beta-SR)(More)
2014 Some experimental results on the macroscopic spreading of hanging and sessile drops on smooth surfaces are presented. The results for sessile drops nicely corroborate the main aspects of the spreading theory of de Gennes and Joanny. However, it is shown that one assumption of the theory, namely the retainment of a self-similar shape during spreading,(More)
BACKGROUND HIV exposed seronegative (HESN) women represent the population most in need of a prophylactic antiviral strategy. Mucosal cationic polypeptides can potentially be regulated for this purpose and we here aimed to determine their endogenous expression and HIV neutralizing activity in genital secretions of women at risk of HIV infection. (More)
2014 We discuss a statistical model for microemulsions, inspired by an idea of Talmon and Prager (but with certain modifications). The surfactant is assumed to be insoluble in both oil and water, and to be distributed in thin sheets, separating oil and water regions. The sheet has a persistence length 03BEK. Consecutive pieces (of area 03BE2K) have(More)