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Nicotinic acetylcholine receptors have been shown to participate in neuroprotection in the aging brain. Lynx protein modulators dampen the activity of the cholinergic system through direct interaction with nicotinic receptors. Although lynx1 null mutant mice exhibit augmented learning and plasticity, they also exhibit macroscopic vacuolation in the dorsal(More)
The effects of (D-Ala2)-Met-enkephalin (DAME) on the nictitating membrane contraction induced by either cervical sympathetic nerve stimulation or i.v. administration of norepinephrine were assessed in anesthetized cats. The contraction induced by sympathetic nerve stimulation (0.5--16 Hz) was greatly reduced by pretreatment with DAME (300 micrograms/kg,(More)
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