Pauline Byrne

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Malignant mesothelioma (MM) is a tumor of the pleura with an etiology that has been strongly linked to previous asbestos exposure. It is an almost universally fatal disease, regardless of tumor stage at the time of diagnosis. Current treatment modalities include surgery, chemotherapy and radiation therapy, although in some clinical trials none of these(More)
BACKGROUND In the United States, there is a shortage of blood group phenotype-matched red cells (RBCs) for patients with sickle cell disease (SCD). A protocol designed to supply phenotype-matched RBCs for these patients by combining the recruitment of African American blood donors and automated testing of RBCs for these patients for the presumptive Fy(a-b-)(More)
The tumor suppressor gene, p53, is the most commonly mutated gene associated with cancer. Mutation of p53 plays a critical role in the multiple stages of carcinogenesis. The functional inactivation of p53 by missense mutations has been described in various cancers and the majority of these mutations occur in exons 5 through 9 of the p53 gene. Mutations(More)
This and the following two papers describe historically the development of courses for general practice teachers in Manchester from 1966. The first paper describes the early attempts to fashion an appropriate course, discusses the content of such courses and the methods used. The second and third papers then discuss a course on non-directive behavioural(More)
Our analysis of real consultations in general practice suggests that eye contact and movements of the body are extremely important in effecting communication between patients and doctors. We have studied non-verbal behaviour in relation to verbal exchanges, and believe that non-verbal behaviour can aid or hinder communication and may sometimes prevent it.We(More)
A battery of assessment measures, including MCQ measures of factual recall, MEQ measures of problem-solving skills, measures of attitudes, intelligence and ability, and personality factors, was administered to the trainee intakes of a number of post-graduate training courses for general practice on a pre-course/post-course basis (trainee sample N = 80). The(More)
Renal transplantation has extended the duration and quality of life for a growing number of women in the Republic of Ireland. Pregnancy has now become a reasonable and viable option for women who were previously too ill to conceive, leading the Royal college of Obstetricians and Gynaecologists to issue opinions on the management of women with renal disease(More)
BACKGROUND For people on peritoneal dialysis (PD), constipation is associated with technique failure. For those on haemodialysis (HD), constipation has been associated with a reduction in quality of life. OBJECTIVES The objectives of this study were to (i) determine the prevalence of functional constipation; (ii) compare patient perception of constipation(More)