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OBJECTIVE To test the hypothesis that in mesial temporal lobe epilepsy (MTLE) there is involvement outside of mesial structures and that this involvement affects serotonin systems, thus suggesting a mechanism for affective symptoms in this population. METHODS Serotonin 5-HT1A receptor binding was studied with PET and [Carbonyl-11C]WAY-100 635 in 14(More)
One working hypothesis behind transsexuality is that the normal sex differentiation of certain hypothalamic networks is altered. We tested this hypothesis by investigating the pattern of cerebral activation in 12 nonhomosexual male-to-female transsexuals (MFTRs) when smelling 4,16-androstadien-3-one (AND) and estra-1,3,5(10),16-tetraen-3-ol (EST). These(More)
The article reports and discusses a long-term qualitative study of forty 8–10-year-old students who regularly played a math game during math lessons for 9 weeks. The goal was to explore the relations between (i) some of the pedagogical principles that underlie the game and (ii) the playing practice in terms of what actually takes place when students play(More)
The mechanism by which anoxia blocks impulse conduction was studied in isolated sciatic nerves from the rat. The desheathed nerve was mounted in a recording chamber, and the compound action potential (CAP) was measured at controlled temperature (23 and 37 degrees C). When the nerve was irrigated with nitrogenated Ringer's solution compound action potential(More)
Thermal sensibility was quantitatively assessed in the feet of 46 diabetic patients. In subjects with sensibility deficits the perception threshold for warmth or cold, or of heat pain, was either increased or lost. Four stages of impaired thermal sensibility were defined, and a classification of dysfunction is proposed which could be useful in routine(More)
An interesting class of intelligent tutoring systems are systems that are able to detect and recognize affective responses and states in students, and use such data to adapt its feedback, guidance and instruction. The article presents affective responses and states considered relevant for learning, and methods that have been proposed or used to detect such(More)
OBJECTIVES To determine if the recovery of nerve function after ischaemic block is impaired in patients with diabetes mellitus relative to healthy controls. METHODS Median nerve impulse conduction and vibratory thresholds in the same innervation territory were studied in patients with diabetes mellitus (n = 16) and age matched controls (n = 10) during and(More)
Symbol sense refers to " a complex and multifaceted " feel " for symbols. " (Arcavi, 1994). We are interested to find out how more skilled and less skilled students read mathematical representations such as formulas, graphs and diagrams by empirically test implications of symbol sense in mathematics by using eye tracking. In addition to acquire skills in(More)
Understanding means identifying and using a structure. The core of understanding consists in identifying relevant relations between objects, between parts and their relation to the whole that is to be understood. Identifying relations contributes to enhanced understanding since finding more relations makes it possible to understand from different points of(More)