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A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.
Lysine methylation occurs on both histone and nonhistone proteins. However, our knowledge on the prevalence and function of nonhistone protein methylation is poor. We describe an approach thatExpand
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An Enhanced Mass Spectrometry Approach Reveals Human Embryonic Stem Cell Growth Factors in Culture*S
The derivation and long-term maintenance of human embryonic stem cells (hESCs) has been established in culture formats that are both dependent and independent of support (feeder) cells. However, theExpand
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Identification of the Flagellin Glycosylation System in Burkholderia cenocepacia and the Contribution of Glycosylated Flagellin to Evasion of Human Innate Immune Responses*
Background: The role of flagellin glycosylation is not well understood. Results: The Burkholderia cenocepacia flagellin is glycosylated on at least 10 different sites. Conclusion: The presence ofExpand
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Increased Expression of GM1 Detected by Electrospray Mass Spectrometry in Rat Primary Embryonic Cortical Neurons Exposed to Glutamate Toxicity.
Neurons within different brain regions have varying levels of vulnerability to external stress and respond differently to injury. A potential reason to explain this may lie within a key lipid classExpand
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The Antarctic Psychrophile Chlamydomonas sp. UWO 241 Preferentially Phosphorylates a Photosystem I-Cytochrome b6/f Supercomplex1[OPEN]
An Antarctic alga exhibits differential phosphorylation of thylakoid membrane proteins, which are part of a photosytem I supercomplex involved in cyclic electron flow. Chlamydomonas sp. UWO 241 (UWOExpand
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Comprehensive analysis of flagellin glycosylation in Campylobacter jejuni NCTC 11168 reveals incorporation of legionaminic acid and its importance for host colonization.
Campylobacter jejuni is the leading cause of bacterial gastroenteritis. It relies on several virulence factors for host colonization, including glycosylated flagella. C. jejuni NCTC 11168 modifiesExpand
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A proteomic strategy to analyze secreted factors from cell culture
Introduction The discovery of secreted factors from cells has been a major focus of proteomic analysis for a number of years, driven both by biomarker discovery as well as understanding how cellsExpand
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Characterization of photosynthetic ferredoxin from the Antarctic alga Chlamydomonas sp. UWO241 reveals novel features of cold adaptation.
The objective of this work was to characterize photosynthetic ferredoxin from the Antarctic green alga Chlamydomonas sp. UWO241, a key enzyme involved in distributing photosynthetic reducing power.Expand
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An Effective Approach for Glycan Structure De Novo Sequencing From HCD Spectra
Mass spectrometry has become a widely used analytical technique for proteomics study because of its high throughput and sensitivity. Among those applications, a specific one is to characterize glycanExpand
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