Paula Marcos-Mondéjar

Learn More
How guidance cues are integrated during the formation of complex axonal tracts remains largely unknown. Thalamocortical axons (TCAs), which convey sensory and motor information to the neocortex, have a rostrocaudal topographic organization initially established within the ventral telencephalon [1-3]. Here, we show that this topography is set in a small hub,(More)
How brain connectivity has evolved to integrate the mammalian-specific neocortex remains largely unknown. Here, we address how dorsal thalamic axons, which constitute the main input to the neocortex, are directed internally to their evolutionary novel target in mammals, though they follow an external path to other targets in reptiles and birds. Using(More)
The assembly of neural circuits is dependent upon the generation of specific neuronal subtypes, each subtype displaying unique properties that direct the formation of selective connections with appropriate target cells. Actions of transcription factors in neural progenitors and postmitotic cells are key regulators in this process. LIM-homeodomain(More)
Ecole Normale Supérieure, Institut de Biologie de l’ENS, IBENS, 46 rue d’Ulm, 75230 PARIS cedex 05, France INSERM, U1024, Avenir Team CNRS, UMR 8197 Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez-Consejo Superior de Investigaciones Científicas (UMH-CSIC), San Joan d’Alacant, 03550, Spain Genentech, Inc., South San Francisco, CA 94080,(More)
  • 1