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Efficacy of systemic administration of SDF-1 in a model of vascular insufficiency: support for an endothelium-dependent mechanism.
OBJECTIVE Studies have reported that administration of stromal cell-derived factor-1 (SDF-1), the ligand for the G-protein coupled receptor CXCR4, increased collateral blood flow in a mouse model of… Expand
Phosphoproteomic evaluation of pharmacological inhibition of leucine‐rich repeat kinase 2 reveals significant off‐target effects of LRRK‐2‐IN‐1
- Gregory C. Luerman, Chuong Nguyen, +9 authors W. Hirst
- Medicine, Biology
- Journal of neurochemistry
- 1 February 2014
Genetic mutations in leucine‐rich repeat kinase 2 (LRRK2) have been linked to autosomal dominant Parkinson's disease. The most prevalent mutation, G2019S, results in enhanced LRRK2 kinase activity… Expand
Application of multiplexed capillary electrophoresis with laser-induced fluorescence (MCE-LIF) detection for the rapid measurement of endogenous extracellular signal-regulated protein kinase (ERK)…
- Jian Tu, LaShonda N. Anderson, +7 authors K. Wehmeyer
- Medicine, Chemistry
- Journal of chromatography. B, Analytical…
- 15 June 2003
Multiplexed (96-lane) capillary electrophoresis with laser-induced fluorescence (MCE-LIF) detection was used for the rapid analysis of extracellular signal-regulated protein kinase (ERK) levels from… Expand
Human A53T α-Synuclein Causes Reversible Deficits in Mitochondrial Function and Dynamics in Primary Mouse Cortical Neurons
Parkinson’s disease (PD) is the second most common neurodegenerative disease. A key pathological feature of PD is Lewy bodies, of which the major protein component is α-synuclein (α-syn). Human… Expand
MAP4K4 Is a Threonine Kinase That Phosphorylates FARP1.
- Adam G. Schwaid, Chunyan Su, +9 authors P. Carpino
- Biology, Medicine
- ACS chemical biology
- 30 September 2015
Mitogen-activated protein kinase 4 (MAP4K4) regulates the MEK kinase cascade and is implicated in cytoskeletal rearrangement and migration; however, identifying MAP4K4 substrates has remained a… Expand