Paula J. Haynes

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Directional growth is a function of polarized cells such as neurites, pollen tubes, and fungal hyphae. Correct orientation of the extending cell tip depends on signaling pathways and effectors that mediate asymmetric responses to specific environmental cues. In the hyphal form of the eukaryotic fungal pathogen Candida albicans, these responses include(More)
Personal control and responsibility are key themes in the therapeutic use of 'motivational interviewing'. This popular method of counselling has suggested that clients need to believe they have a significant degree of control over their behaviour if they are to make progress. Using a well validated psychological test on locus of control of behaviour, our(More)
The prostaglandin-synthetase inhibitors, mefenamic acid and flufenamic acid, were compared with the analgesic, dextropropoxyphene/paracetamol, in the treatment of primary dysmenorrhoea in a double-blind crossover trial. Results were assessed in 30 patients who took each drug during menstruation for three consecutive cycles. The patients' assessment of each(More)
Six patients with menorrhagia due to dysfunctional uterine bleeding and one patient with an intrauterine contraceptive device were treated with prostaglandin-synthetase inhibitors in an attempt to reduce their excessive menstrual blood-loss. Mefenamic acid (six patients) or flufenamic acid (one patient) taken during menstruation for 2-3 cycles reduced(More)
A study has been made of menstrual blood loss measured in 50 women with unexplained heavy loss (more than 80 ml). Twelve of these women had an average menstrual loss greater than 200 ml, five women in excess of 450 ml. There was no relation between the duration of menstruation and the total menstrual blood loss. Compared to women with normal menstrual loss(More)
The extremely elongated morphology of fungal hyphae is dependent on the cell's ability to assemble and maintain polarized growth machinery over multiple cell cycles. The different morphologies of the fungus Candida albicans make it an excellent model organism in which to study the spatiotemporal requirements for constitutive polarized growth and the(More)
The potential of Norway rats (Rattus norvegicus) to spread the parasite Cryptosporidium parvum was investigated by examining parasite prevalence in relation to the structure and movements of three permanent rat populations living on farmland in Warwickshire (UK) from October 1994 to March 1997. One population lived among a group of farm buildings housing(More)
Concentrations of oxytocin have been measured in plasma samples obtained daily from 6 women throughout complete menstrual cycles. Measurements of menstrual blood loss and plasma levels of luteinizing hormone (LH), progesterone and 17beta-oestradiol suggested that normal ovulatory cycles were studied. A significant elevation in the circulating concentration(More)