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The ability to repeatedly regenerate limbs during the entire lifespan of an animal is restricted to certain salamander species among vertebrates. This ability involves dedifferentiation of post-mitotic cells into progenitors that in turn form new structures. A long-term enigma has been how injury leads to dedifferentiation. Here we show that skeletal muscle(More)
Salamander limb regeneration depends on local progenitors whose progeny are recruited to the new limb. We previously identified a Pax7(+) cell population in skeletal muscle whose progeny have the potential to contribute to the regenerating limb. However, the plasticity of individual Pax7(+) cells, as well as their recovery within the new limb, was unclear.(More)
The central nervous system has been implicated in the activation of counterregulatory hormone release during hypoglycemia. However, the precise loci involved are not established. To determine the role of the ventromedial hypothalamic nuclei (VMH) in the hormonal response to hypoglycemia, we performed hypoglycemic clamp studies in conscious SpragueDawley(More)
Regeneration is unevenly spread throughout the animal kingdom. Some of the invertebrates have a very high regenerative capacity but the capacity to replace lost or damaged tissues in mammals is limited. Among the vertebrates, the aquatic salamanders are the champions of regeneration, being able to regenerate body parts such as their limbs, tail, and jaw.(More)
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