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Gap junctions have traditionally been characterized as nonspecific pores between cells passing molecules up to 1 kDa in molecular mass. Nonetheless, it has become increasingly evident that different members of the connexin (Cx) family mediate quite distinct physiological processes and are often not interchangeable. Consistent with this observation,(More)
Although gap junction channels are still widely viewed as large, non-specific pores connecting cells, the diversity in the connexin family has led more attention to be focused on their permeability characteristics. We summarize here the current status of these investigations, both published and on-going, that reveal both charge and size selectivity between(More)
Event-related potentials (ERPs) have been used extensively to study the processes involved in recognition memory. In particular, the early familiarity component of recognition has been linked to the FN400 (mid-frontal negative deflection between 300 and 500 ms), whereas the recollection component has been linked to a later positive deflection over the(More)
As ubiquitous conduits for intercellular transport and communication, gap junctional pores have been the subject of numerous investigations aimed at elucidating the molecular mechanisms underlying permeability and selectivity. Dye transfer studies provide a broadly useful means of detecting coupling and assessing these properties. However, given evidence(More)
PURPOSE To develop a method for evaluating viscosity and elasticity of the cornea and to examine the effect that both properties have on hysteresis. METHODS A three-component spring and dashpot model was created in Simulink in Matlab to represent the purely elastic and viscoelastic behavior of the cornea during a measurement using device called an ocular(More)
PURPOSE This study tested the hypothesis that intraocular pressure (IOP) elevations, induced by controlled increase of intraocular volume, are correlated with the biomechanical responses of the posterior sclera. METHODS Porcine globes were tested within 48 hours postmortem. The first group of globes (n = 11) was infused with 15 μL of phosphate-buffered(More)
PURPOSE To experimentally examine the effect of increased corneal stiffness on Goldmann applanation tonometry (GAT) and Tono-Pen (Reichert, Inc., Depew, NY) measurements of intraocular pressure (IOP) in a canine eye model. METHODS Twenty globes were recovered from 10 dogs with no known diseases. For each dog, corneal stiffening was induced in one eye with(More)