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Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

• Niall C. Tebbutt, Andrew S. Giraud, +9 authors Matthias Ernst
• Nature Medicine
• 2002

The intracellular signaling mechanisms that specify tissue-specific responses to the interleukin-6 (IL-6) family of cytokines are not well understood. Here, we evaluated the functions of the two… (More)

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling

• Brendan J Jenkins, Dianne Grail, +13 authors Matthias Ernst
• Nature Medicine
• 2005

The latent transcription factor Stat3 is activated by gp130, the common receptor for the interleukin (IL)-6 cytokine family and other growth factor and cytokine receptors. Ligand-induced dimerization… (More)

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

• Bijay S. Jaiswal, Vasantharajan Janakiraman, +21 authors Somasekar Seshagiri
• Cancer cell
• 2009

Members of the mammalian phosphoinositide-3-OH kinase (PI3K) family of proteins are critical regulators of various cellular process including cell survival, growth, proliferation, and motility.… (More)

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.

• Kathryn M. Kinross, Karen G. Montgomery, +18 authors Wayne A Phillips
• The Journal of clinical investigation
• 2012

Mutations in the gene encoding the p110α subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in human cancers. To better understand the role of mutant PIK3CA in the… (More)

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1.

• Kelly A. Loffler, Christine A Biondi, +6 authors Graham F. Kay
• International journal of cancer
• 2007

Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer predisposition syndrome typified by development of tumors in parathyroid, pituitary and endocrine pancreas, as well as less common… (More)

Redox active calcium ion channels and cell death.

• Paul Waring
• Archives of biochemistry and biophysics
• 2005

Calcium plays a key role in both apoptotic and necrotic cell death. Emptying of intracellular calcium stores and/or alteration in intracellular calcium levels can modulate cell death in almost all… (More)

In vivo immunosuppressive activity of gliotoxin, a metabolite produced by human pathogenic fungi.

• Phil Sutton, Nicole Newcombe, Paul Waring, Arno Müllbacher
• Infection and immunity
• 1994

Aspergillosis is a disease caused by the opportunistic pathogen Aspergillus fumigatus and other related fungi. It occurs mainly in immunosuppressed people and causes very high mortality rates. A… (More)

Gliotoxin and related epipolythiodioxopiperazines.

• Paul Waring, J P Beaver
• General pharmacology
• 1996

1. Gliotoxin belongs to the epipolythiodioxopiperazine class of secondary metabolites. These compounds show a diverse range of biological activity including antimicrobial, antifungal and antiviral… (More)

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines.

• Paul Waring, R D Eichner, Arno Müllbacher
• Medicinal research reviews
• 1988

Lack of correlation between early intracellular calcium ion rises and the onset of apoptosis in thymocytes.

• J P Beaver, Paul Waring
• Immunology and cell biology
• 1994

Apoptosis, a well-recognized process of cell death, is usually defined by chromatin condensation, plasma membrane blebbing, reduction in cell volume, and in many cell types the cleavage of DNA into… (More)

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