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Ingestion of potassium iodide (KI) offers effective protection against irradiation of the thyroid after accidental exposure to radioactive iodine. This prophylaxis aims at rapidly obtaining maximal thyroid protection without adverse effects. This article reviews studies on iodine kinetics in humans and on the efficacy of KI in protecting the thyroid. In(More)
In vivo cardiovascular function of sedentary and exercise-trained rats were studied after a 3 week feeding period of diets containing either 10% fish oil, sunflower oil or lard. Rats were randomly assigned to six groups: fish oil diet: sedentary (FS), exercise-trained (FT); sunflower oil diet; sedentary (SS), exercise-trained (ST); lard diet: sedentary(More)
Haemochromatosis is a common autosomal recessive genetic disorder of iron metabolism. A candidate gene was recently identifed (HLA-H) and two amino acid substitutions (C282Y and H63D) were characterized. Haemochromatosis probands (n = 478) from Brittany were selected from their iron status markers, primarily serum iron, serum ferritin and transferrin(More)
Pedigree analysis has shown a close linkage between the loci for the Rh blood group and elliptoeytosis (El i) (Chalmers and Lawler, 1953) and between the loci for Rh and 6 phosphogluconate dehydrogenase (6 PGD) (Weitkamp, 1971). Use of interspeeifie somatic-cell hybrids has demonstrated the synteny of phosphoglucomutase 1 (PGM 1) and 6 PGD (Westerweld and(More)
Ausgehend von einem Knaben mit nichtsphärocytärer hämolytischer Anämie, bei welchem wir einen Pyruvat-Kinase-Mangel feststellen konnten, wurde die Erythrocyten-PK aller Familienmitglieder, darunter zweier Heterozygoter, bezüglich Enzymkinetik untersucht. Nach partieller Reinigung über Sephadex G-100 wurde die Michaelis-Konstante für PEP und ADP sowie die(More)
Osteo-onychodysostosis, formerly nail-patella syndrome, is characterized by abnormal nails and dysplasia of the knees, elbows, and pelvis, and occasionally nephropathy. This rare disorder is produced by a single gene and has an autosomal pattern of inheritance with full penetrance. The "nail-patella" locus (NP) lies beside the AB0 blood group locus (Renwick(More)
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