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Doublecortin (DCX) is a microtubule-associated protein required for neuronal migration to the cerebral cortex. DCAMKL1 consists of an N terminus that is 65% similar to DCX throughout the entire length of DCX, but also contains an additional 360 amino acid C-terminal domain encoding a putative Ca(2+)/calmodulin-dependent protein kinase. The homology to DCX(More)
This paper explores the development of a scalable, nonlinear, fully-implicit stabilized unstructured finite element (FE) capability for 2D incompressible (reduced) resistive MHD. The discussion considers the implementation of a stabilized FE formulation in context of a fully-implicit time integration and direct-to-steady-state solution capability. The(More)
Application performance is determined by a combination of many choices: hardware plat-form, runtime environment, languages and compilers used, algorithm choice and implementation, and more. In this complicated environment, we find that the use of mini-applications - small self-contained proxies for real applications - is an excellent approach for rapidly(More)
Computational science and engineering application programs are typically large, complex, and dynamic, and are often constrained by distribution limitations. As a means of making tractable rapid explorations of scientific and engineering application programs in the context of new, emerging, and future computing architectures, a suite of ‘‘miniapps’’ has been(More)
Acute cerebral ischemia remains a major cause for death and disability but current therapeutic options are limited. A mixture of biological agents extracted from the inflamed rabbit skin induced by inoculation of vaccinia virus has been shown to reduce ischemia-induced cerebral edema in vivo. In the current study we show that treatment with such a mixture(More)
The Red Storm architecture, which was conceived by Sandia National Laboratories and implemented by Cray, Inc., has become the basis for most successful line of commercial supercomputers in history. The success of the Red Storm architecture is due largely to the ability to effectively and efciently solve a wide range of science and engineering problems. The(More)
An implicit multigrid-driven algorithm for two-dimensional incompressible laminar viscous ows has been coupled with a solution adaptation method and a mesh movement method for boundary movement. Time-dependent calculations are performed implicitly by regarding each time step as a steady-state problem in pseudo-time. The method of arti cial compressibility(More)