Paul T. Cernek

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Transient protein-protein interactions (PPIs), which underly most biological processes, are a prime target for therapeutic development. Immense progress has been made towards computational prediction of PPIs using methods such as protein docking and sequence analysis. However, docking generally requires high resolution structures of both of the binding(More)
Surface area as derived by MSMS [1] was obtained per residue and then divided by the solvent excluded surface area of the mean maximum residue surface area (MMRSA) for the residue's type. The MMRSA was calculated using UCSF Chimera [2], simulating each residue in a GLY-X-GLY tri-peptide and averaging surface area values over 5 different secondary structures(More)
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